SH3GL1 and DPPA4

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SH3GL1	DPPA4
Description		SH3 domain containing GRB2 like 1, endophilin A2	developmental pluripotency associated 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Early Endosome Membrane Cell Projection Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Protein C-terminus Binding Lipid Binding SH3 Domain Binding Phosphatase Binding Beta-1 Adrenergic Receptor Binding Identical Protein Binding Transmembrane Transporter Binding Cadherin Binding GTPase Binding	Chromatin Binding Protein Binding
	Biological Process	Signal Transduction Central Nervous System Development Synaptic Vesicle Uncoating Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Endocytosis	System Development Lung-associated Mesenchyme Development
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Red cell distribution width ( 32888494)	Cardiac hypertrophy ( 21348951) Corneal astigmatism ( 23761726) Metabolite levels ( 23823483)
Interacting Genes		37 interacting genes: ARHGAP1 ARHGAP8 AXIN1 B3GAT1 CCDC50 CMTM5 CREBBP DNM1 DNM1L DPPA4 DPYSL4 FAM102A FBXO32 GPKOW ITCH ITSN2 MAL2 MTA1 NUTM2F PDCD6IP PML PRB3 PRR5-ARHGAP8 PSMB1 PTPRO RHEX SCAMP5 SEPTIN8 SH2D4A SH3D19 SH3GL3 SOCS1 SPG21 STK11 SYNJ1 VPS37C YWHAZ	35 interacting genes: BTBD2 CIR1 CRK DPPA2 EAF1 EIF4A2 EMD FOXR1 GMPPB GRAP GRB2 GTPBP3 HTT INO80B KAT14 LDOC1 MAGOH MAPK6 MISP NEDD9 OSTF1 PLEKHF2 PTPRO QARS1 RPGRIP1 RPS6KB1 SH3GL1 SH3GL2 SH3GL3 SNX18 SNX33 SPANXN2 TLK1 TNIP1 VIM
Entrez ID		6455	55211
HPRD ID		03462	16836
Ensembl ID		ENSG00000141985	ENSG00000121570
Uniprot IDs		Q6FGM0 Q99961	Q7L190
PDB IDs
Enriched GO Terms of Interacting Partners?
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