ITSN1 and ASAP2

Number of citations of the paper that reports this interaction (PubMedID 18654987)
21

Data Source:
BioGRID (two hybrid)

		ITSN1	ASAP2
Description		intersectin 1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Lamellipodium Presynaptic Membrane Neuronal Cell Body Dendritic Spine Recycling Endosome Apical Dendrite Intracellular Vesicle Presynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse	Plasma Membrane Golgi Cisterna Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Molecular Adaptor Activity Proline-rich Region Binding	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Exocytosis Endocytosis Brain Development Protein Transport Endosomal Transport Cellular Protein Localization Intracellular Signal Transduction Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Dendritic Spine Development Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Caveolin-mediated Endocytosis	Positive Regulation Of GTPase Activity
Pathways		NRAGE signals death through JNK EPHB-mediated forward signaling EPHB-mediated forward signaling G alpha (12/13) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis CDC42 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Bitter non-alcoholic beverage consumption ( 31046077) Educational attainment ( 25201988) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) QT interval ( 29213071) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252) Tonsillectomy ( 27182965 28928442)	Bipolar disorder ( 31043756) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease ( 30804561) Chronic widespread musculoskeletal pain ( 33331911) Pulse pressure ( 27841878 30578418) Urate levels ( 31578528)
Interacting Genes		93 interacting genes: AGFG1 AGFG2 AKT1 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CBR3 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 DSC2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHO1 FCHO2 FCHSD2 FNBP1 FNBP4 GAREM2 GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAP3K20 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 PRRG4 RAB11FIP2 RAB5A RABEP1 RAI14 RCAN1 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SGIP1 SH3GL2 SHANK3 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 VLDLR WASL WBP11 ZFPM2	15 interacting genes: APC ARF1 ARF5 ARF6 BIN1 GRB2 ITSN1 PACSIN3 PTK2B PXN RAN REPS2 RRM2 SH3KBP1 THSD7A
Entrez ID		6453	8853
HPRD ID		03898	04820
Ensembl ID		ENSG00000205726	ENSG00000151693
Uniprot IDs		A7XZY7 F8W7U0 Q15811 Q6PD56	O43150
PDB IDs		1KI1 2KGR 2KHN 3FIA 3QBV 4IIM 5HZI 5HZJ 5HZK 6GBU 6H5T
Enriched GO Terms of Interacting Partners?
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