ITSN1 and ARFIP2

Number of citations of the paper that reports this interaction (PubMedID 22558309)
25

Data Source:
BioGRID (two hybrid, protein complementation assay, affinity chromatography technology)

		ITSN1	ARFIP2
Description		intersectin 1	ADP ribosylation factor interacting protein 2
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GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Lamellipodium Presynaptic Membrane Neuronal Cell Body Dendritic Spine Recycling Endosome Apical Dendrite Intracellular Vesicle Presynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse	Ruffle Cytoplasm Cytosol Plasma Membrane Cell Cortex Trans-Golgi Network Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Molecular Adaptor Activity Proline-rich Region Binding	Protein Binding GTP Binding Phospholipid Binding Protein Domain Specific Binding GTP-dependent Protein Binding Small GTPase Binding Identical Protein Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Membrane Curvature Sensor Activity
	Biological Process	Exocytosis Endocytosis Brain Development Protein Transport Endosomal Transport Cellular Protein Localization Intracellular Signal Transduction Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Dendritic Spine Development Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Caveolin-mediated Endocytosis	Intracellular Protein Transport Autophagy Small GTPase Mediated Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		NRAGE signals death through JNK EPHB-mediated forward signaling EPHB-mediated forward signaling G alpha (12/13) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis CDC42 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Bitter non-alcoholic beverage consumption ( 31046077) Educational attainment ( 25201988) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) QT interval ( 29213071) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252) Tonsillectomy ( 27182965 28928442)	Malaria ( 31844061)
Interacting Genes		93 interacting genes: AGFG1 AGFG2 AKT1 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CBR3 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 DSC2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHO1 FCHO2 FCHSD2 FNBP1 FNBP4 GAREM2 GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAP3K20 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 PRRG4 RAB11FIP2 RAB5A RABEP1 RAI14 RCAN1 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SGIP1 SH3GL2 SHANK3 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 VLDLR WASL WBP11 ZFPM2	63 interacting genes: AGTRAP AKT1 APP ARF1 ARF3 ARF5 ARF6 ARFIP1 ARL1 BLOC1S2 C19orf25 CDKN2A CDR1 CEP63 CMTM5 CYTH3 DGAT2L6 DMAP1 DTNBP1 FADS6 FSD2 GOLGA2 GSG1 HAUS1 HGS ING5 ITGB3BP ITSN1 KRT15 KRT16 LNX1 LY6D MAL2 MIEF1 MIEF2 NDRG4 NFE2L2 NRDE2 NUP62 PBX3 PKNOX2 PLP2 PPIF PUM3 RAC1 RAC2 RAC3 REEP5 REL RND1 SCAMP1 SCAMP5 SDCBP SH3GLB1 SMG9 SNX1 SOCS2 STAT3 SYP TMEM255B TRIM54 TTPA USHBP1
Entrez ID		6453	23647
HPRD ID		03898	07209
Ensembl ID		ENSG00000205726	ENSG00000132254
Uniprot IDs		A7XZY7 F8W7U0 Q15811 Q6PD56	A0A087X1E4 B4DUZ3 B4DXH2 P53365
PDB IDs		1KI1 2KGR 2KHN 3FIA 3QBV 4IIM 5HZI 5HZJ 5HZK 6GBU 6H5T	1I49 1I4D 1I4L 1I4T 4DCN
Enriched GO Terms of Interacting Partners?
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