SFTPB and CTSH

Number of citations of the paper that reports this interaction (PubMedID 14766755)
34

Data Source:
HPRD (in vitro)

		SFTPB	CTSH
Description		surfactant protein B	cathepsin H
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Alveolar Lamellar Body Multivesicular Body Lumen	Extracellular Region Extracellular Space Lysosome Cytosol Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Alveolar Lamellar Body Multivesicular Body Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding	Endopeptidase Activity Aminopeptidase Activity Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process HLA-A Specific Activating MHC Class I Receptor Activity Thyroid Hormone Binding
	Biological Process	Sphingolipid Metabolic Process Respiratory Gaseous Exchange By Respiratory System Animal Organ Morphogenesis	Metanephros Development T Cell Mediated Cytotoxicity Adaptive Immune Response Immune Response-regulating Signaling Pathway Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Neuropeptide Catabolic Process Bradykinin Catabolic Process Positive Regulation Of Peptidase Activity Antigen Processing And Presentation Positive Regulation Of Cell Migration Zymogen Activation Protein Destabilization Response To Retinoic Acid Membrane Protein Proteolysis Negative Regulation Of Apoptotic Process Surfactant Homeostasis Positive Regulation Of Angiogenesis Proteolysis Involved In Cellular Protein Catabolic Process Dichotomous Subdivision Of Terminal Units Involved In Lung Branching ERK1 And ERK2 Cascade Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Surfactant metabolism Defective pro-SFTPB causes SMDP1 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4	MHC class II antigen presentation Surfactant metabolism Neutrophil degranulation
Drugs			N1-(1-Dimethylcarbamoyl-2-Phenyl-Ethyl)-2-Oxo-N4-(2-Pyridin-2-Yl-Ethyl)-Succinamide p-Toluenesulfonic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONE
Diseases
GWAS		Blood protein levels ( 30072576)	Aspartate aminotransferase levels ( 33547301) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203) Bipolar disorder ( 21771265) Blood protein levels ( 30072576 29875488) Celiac disease ( 30572963) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 31604244 24076602) Narcolepsy ( 23459209) Type 1 diabetes ( 25751624 19430480 30572963 18978792)
Interacting Genes		3 interacting genes: CTSH GRPEL1 MEOX2	5 interacting genes: BGLAP CSTA CSTB SFTPB XRN1
Entrez ID		6439	1512
HPRD ID		01523	00288
Ensembl ID		ENSG00000168878	ENSG00000103811
Uniprot IDs		D6W5L6 P07988	E9PKT6 P09668
PDB IDs		1DFW 1KMR 1RG3 1RG4 1SSZ 2DWF 2JOU 2M0H 2M1T	1BZN 6CZK 6CZS
Enriched GO Terms of Interacting Partners?
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