CTSH and CSTB

Number of citations of the paper that reports this interaction (PubMedID 11514663)
5

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		CTSH	CSTB
Description		cathepsin H	cystatin B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Cytosol Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Alveolar Lamellar Body Multivesicular Body Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Endopeptidase Activity Aminopeptidase Activity Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process HLA-A Specific Activating MHC Class I Receptor Activity Thyroid Hormone Binding	Protease Binding RNA Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity
	Biological Process	Metanephros Development T Cell Mediated Cytotoxicity Adaptive Immune Response Immune Response-regulating Signaling Pathway Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Neuropeptide Catabolic Process Bradykinin Catabolic Process Positive Regulation Of Peptidase Activity Antigen Processing And Presentation Positive Regulation Of Cell Migration Zymogen Activation Protein Destabilization Response To Retinoic Acid Membrane Protein Proteolysis Negative Regulation Of Apoptotic Process Surfactant Homeostasis Positive Regulation Of Angiogenesis Proteolysis Involved In Cellular Protein Catabolic Process Dichotomous Subdivision Of Terminal Units Involved In Lung Branching ERK1 And ERK2 Cascade Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Apoptotic Signaling Pathway	Adult Locomotory Behavior Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Proteolysis
Pathways		MHC class II antigen presentation Surfactant metabolism Neutrophil degranulation	Neutrophil degranulation
Drugs		N1-(1-Dimethylcarbamoyl-2-Phenyl-Ethyl)-2-Oxo-N4-(2-Pyridin-2-Yl-Ethyl)-Succinamide p-Toluenesulfonic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONE	Cupric Chloride
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203) Bipolar disorder ( 21771265) Blood protein levels ( 30072576 29875488) Celiac disease ( 30572963) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 31604244 24076602) Narcolepsy ( 23459209) Type 1 diabetes ( 25751624 19430480 30572963 18978792)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		5 interacting genes: BGLAP CSTA CSTB SFTPB XRN1	11 interacting genes: COL6A1 CST3 CTSB CTSD CTSH CTSL ECT2 ERG RAD21 RUNX1 SPRY2
Entrez ID		1512	1476
HPRD ID		00288	03091
Ensembl ID		ENSG00000103811	ENSG00000160213
Uniprot IDs		E9PKT6 P09668	P04080 Q76LA1
PDB IDs		1BZN 6CZK 6CZS	1STF 2OCT 4N6V
Enriched GO Terms of Interacting Partners?
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