KIF9 and PRMT6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		KIF9	PRMT6
Description		kinesin family member 9	protein arginine methyltransferase 6
Image
GO Annotations	Cellular Component	Podosome Cytoplasm Kinesin Complex Microtubule Vesicle	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP Hydrolysis Activity Identical Protein Binding	Chromatin Binding Protein Binding Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H4-R3 Specific) Histone Methyltransferase Activity (H3-R2 Specific) Histone Methyltransferase Activity (H2A-R3 Specific)
	Biological Process	Microtubule-based Movement Extracellular Matrix Disassembly Regulation Of Podosome Assembly Organelle Disassembly	Negative Regulation Of Transcription By RNA Polymerase II Base-excision Repair Regulation Of Mitochondrion Organization Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Negative Regulation Of Histone Deacetylation Histone H3-R2 Methylation Histone H4-R3 Methylation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Histone H3-K4 Methylation Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator
Pathways		COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins	RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Adiponectin levels ( 31178129) Huntington's disease progression ( 28642124) Platelet count ( 32888494) Platelet distribution width ( 32888494) Refractive error ( 32231278) Type 2 diabetes ( 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Adult body size ( 32376654) Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Refractive error ( 32231278) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		63 interacting genes: ACBD4 ALAS1 AMOTL2 ATP5IF1 BLZF1 CARD9 CCDC125 CYTIP DISC1 EFHC2 EMD FXR1 GOLGA6A HMBOX1 HOOK2 HSF2BP IHO1 IKZF1 IKZF3 INKA1 IQCB1 JAKMIP2 KANK2 KCTD9 KRT75 KRTAP10-3 KRTAP10-6 KRTAP10-9 LZTS1 LZTS2 MAD1L1 MID1 MID2 MIPOL1 NAB2 OIP5 OOEP PIBF1 PNMA5 PPP1R13B PRICKLE1 PRMT6 RBM48 RBM5 ROPN1 SHISA6 SLAIN1 SSX2IP STEEP1 TFIP11 TRIM27 TRIM37 TRIM54 VIM VPS52 ZBTB8A ZC2HC1C ZCCHC7 ZNF417 ZNF436 ZNF566 ZNF572 ZRANB1	90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4-16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9
Entrez ID		64147	55170
HPRD ID		07444	10505
Ensembl ID		ENSG00000088727	ENSG00000198890
Uniprot IDs		A8K932 Q9HAQ2	Q96LA8
PDB IDs		3NWN	4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?