RRAGC and DEPDC5

Number of citations of the paper that reports this interaction (PubMedID 23723238)
374

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		RRAGC	DEPDC5
Description		Ras related GTP binding C	DEP domain containing 5, GATOR1 subcomplex subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Intracellular Membrane-bounded Organelle Gtr1-Gtr2 GTPase Complex	Lysosome Lysosomal Membrane Cytosol Perinuclear Region Of Cytoplasm GATOR1 Complex
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Heterodimerization Activity GTPase Binding	GTPase Activator Activity Protein-containing Complex Binding
	Biological Process	Transcription, DNA-templated Apoptotic Process Small GTPase Mediated Signal Transduction RNA Splicing Cellular Response To Starvation Regulation Of Autophagy Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Cellular Protein Localization Response To Amino Acid Cellular Response To Amino Acid Stimulus Regulation Of TORC1 Signaling	Regulation Of Autophagy Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Intracellular Signal Transduction Regulation Of Catalytic Activity Negative Regulation Of TORC1 Signaling
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Blood protein levels ( 28240269)	Age-related hearing impairment ( 24939585) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Chronic hepatitis C infection ( 21725309) Fish- and plant-related diet ( 32066663) Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment ( 33608531) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence ( 22449649) Isthmus-cingulate cortex volume ( 31530798) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Type 2 diabetes ( 30130595)
Interacting Genes		7 interacting genes: ATXN1L DEPDC5 MPP3 NOL8 RRAGA RRAGB WNT2	10 interacting genes: CCT3 DPPA3 MAD2L1 MAD2L2 MEOX2 MTMR9 RRAGB RRAGC SYT17 USP2
Entrez ID		64121	9681
HPRD ID		12198	16795
Ensembl ID		ENSG00000116954	ENSG00000100150
Uniprot IDs		B4DQ03 B4DQG4 Q9HB90	O75140
PDB IDs		3LLU 6CES 6EHR 6NZD 6S6A 6S6D 6SB0 6SB2 6U62 6ULG 6WJ2 6WJ3	6CES 6CET
Enriched GO Terms of Interacting Partners?
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