DEPDC5 and MTMR9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DEPDC5	MTMR9
Description		DEP domain containing 5, GATOR1 subcomplex subunit	myotubularin related protein 9
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Perinuclear Region Of Cytoplasm GATOR1 Complex	Cytoplasm Endoplasmic Reticulum Cytosol Membrane Ruffle Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein-containing Complex Binding	Phosphatidylinositol-3-phosphatase Activity Protein Binding Protein Phosphatase Binding Enzyme Regulator Activity
	Biological Process	Regulation Of Autophagy Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Intracellular Signal Transduction Regulation Of Catalytic Activity Negative Regulation Of TORC1 Signaling	Endocytosis Negative Regulation Of Autophagy Positive Regulation Of Phosphatase Activity Phosphatidylinositol Dephosphorylation Protein Stabilization Regulation Of Phosphatidylinositol Dephosphorylation
Pathways		Amino acids regulate mTORC1	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the late endosome membrane Synthesis of IP2, IP, and Ins in the cytosol
Drugs
Diseases
GWAS		Age-related hearing impairment ( 24939585) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Chronic hepatitis C infection ( 21725309) Fish- and plant-related diet ( 32066663) Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment ( 33608531) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence ( 22449649) Isthmus-cingulate cortex volume ( 31530798) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Type 2 diabetes ( 30130595)	Adventurousness ( 30643258) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) Essential hypertension (time to event) ( 32589924) Extraversion ( 27918536) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) General factor of neuroticism ( 30867560) Processed meat consumption ( 32066663) Refractive error ( 32231278) Retinal vascular caliber ( 21060863) Systemic lupus erythematosus ( 26316170) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		10 interacting genes: CCT3 DPPA3 MAD2L1 MAD2L2 MEOX2 MTMR9 RRAGB RRAGC SYT17 USP2	27 interacting genes: AATK BLK DEPDC5 EMILIN1 ERBB3 ERBB4 EWSR1 FAM169A GRAMD4 INCA1 KDM1A KIAA1328 KRT27 LNX1 MEI4 MOS MTMR6 MTMR7 MTMR8 NECAB2 NMI PTK7 PTPN3 ROR2 SPG21 VAC14 ZNF655
Entrez ID		9681	66036
HPRD ID		16795	09377
Ensembl ID		ENSG00000100150	ENSG00000104643
Uniprot IDs		O75140	Q96QG7
PDB IDs		6CES 6CET
Enriched GO Terms of Interacting Partners?
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