GP1BA and FBXL4

		GP1BA	FBXL4
Description		glycoprotein Ib platelet subunit alpha	F-box and leucine rich repeat protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Anchored Component Of External Side Of Plasma Membrane Extracellular Exosome	Ubiquitin Ligase Complex Mitochondrial Intermembrane Space Cytosol Nuclear Speck SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Thrombin-activated Receptor Activity	Protein Binding
	Biological Process	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Platelet Activation Regulation Of Blood Coagulation Fibrinolysis Thrombin-activated Receptor Signaling Pathway Platelet Aggregation	Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Defective F9 activation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Ibuprofen Egaptivon pegol liposomal prostaglandin E1 Dexibuprofen
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Keratoconus ( 33649486) Mean platelet volume ( 32888494 27863252) Platelet count ( 22139419 29403010 32888494 20139978 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494)	Chronotype ( 30696823) Depression ( 29700475) Experiencing mood swings ( 29500382) Feeling nervous ( 29500382) Major depressive disorder ( 27479909) Metabolite levels ( 23823483) Neurociticism ( 29500382) Regular attendance at a religious group ( 29970889)
Interacting Genes		18 interacting genes: CTSG DDIT3 F11 F12 F2 FBXL4 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP PIK3R1 SELP TPST1 VWF YWHAZ	4 interacting genes: GP1BA MAP3K7 RXRG SKP1
Entrez ID		2811	26235
HPRD ID		01976	05738
Ensembl ID		ENSG00000185245	ENSG00000112234
Uniprot IDs		L7UYB8 P07359	Q9UKA2
PDB IDs		1GWB 1K13 1M0Z 1M10 1OOK 1P8V 1P9A 1QYY 1SQ0 1U0N 2BP3 3P72 3PMH 4C2A 4C2B 4CH2 4CH8 4MGX 4YR6
Enriched GO Terms of Interacting Partners?
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