UBE2O and SFMBT2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		UBE2O	SFMBT2
Description		ubiquitin conjugating enzyme E2 O	Scm like with four mbt domains 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body	Nucleus Nucleoplasm Cytosol Aggresome Nuclear Body Nuclear Speck Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Binding
	Biological Process	Protein Monoubiquitination Negative Regulation Of Endopeptidase Activity Positive Regulation Of BMP Signaling Pathway Retrograde Transport, Endosome To Golgi Negative Regulation Of Apoptotic Process Protein K63-linked Ubiquitination	Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mitochondrial DNA levels ( 25240745) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)	Asthma (childhood onset) ( 31036433) Fasting blood insulin (BMI interaction) ( 22581228) Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Monoclonal gammopathy of undetermined significance ( 30737484)
Interacting Genes		18 interacting genes: APPL1 BAP1 CPNE1 CPNE2 CPNE4 HEXIM1 ITCH MAF MDM2 MXI1 PRKN RNF10 RNF31 SFMBT2 SHBG TRIM27 UBC UBE2D3	11 interacting genes: CLK1 L3MBTL3 LYPLA1 PHC1 SCMH1 SCML1 SCML2 SIAH1 SLF2 TFAP4 UBE2O
Entrez ID		63893	57713
HPRD ID		10928	18853
Ensembl ID		ENSG00000175931	ENSG00000198879
Uniprot IDs		Q9C0C9	Q5VUG0
PDB IDs			1WJR
Enriched GO Terms of Interacting Partners?
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