SFMBT2 and L3MBTL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SFMBT2	L3MBTL3
Description		Scm like with four mbt domains 2	L3MBTL histone methyl-lysine binding protein 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Aggresome Nuclear Body Nuclear Speck Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Binding	Molecular_function Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated	Chromatin Organization Macrophage Differentiation Granulocyte Differentiation Erythrocyte Maturation Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 31036433) Fasting blood insulin (BMI interaction) ( 22581228) Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Monoclonal gammopathy of undetermined significance ( 30737484)	Alanine aminotransferase levels ( 33547301 34315874) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 31043758 27680694) Body mass index ( 25673413) Body shape index ( 34021172) Breast cancer ( 29059683 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) C-reactive protein levels ( 30388399) Chronic kidney disease ( 31152163) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 25429064 23563607 31562340 18391951) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 34021172 25673412) Immature fraction of reticulocytes ( 32888494) Influenza A (H1N1) infection ( 26379185) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 32888494 27863252) Mild influenza (H1N1) infection ( 26379185) Multiple sclerosis ( 31604244 27386562) Offspring birth weight ( 31043758) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Spleen volume ( 34128465) Triglyceride levels ( 32203549 32154731) Triglyceride levels in HIV infection ( 33109212) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		11 interacting genes: CLK1 L3MBTL3 LYPLA1 PHC1 SCMH1 SCML1 SCML2 SIAH1 SLF2 TFAP4 UBE2O	57 interacting genes: ASB6 BANP BYSL C1QTNF4 CRLF3 DEF6 DNMT1 FLAD1 FNDC3B FXR2 GAS8 H3C1 HSF2BP IL16 KANK2 KDM1A LIG1 LMO4 LRRK2 LSM4 LZTR1 MAPK3 MAPK9 MFAP1 MORF4L1 MORF4L2 NGB NRF1 NTAQ1 OAZ3 PDE6G PHC2 PHF21A PIK3R3 PLEKHF1 PLEKHF2 PLOD3 POLR2L PPP2CA PRKAA1 PRKAA2 RHOBTB3 SFMBT2 SNRPB SOX2 SP100 SPANXN2 SUFU SUMO1P1 TBC1D1 TCEANC THRA TRAF3IP3 TSTD2 TTC19 ZCWPW1 ZNF76
Entrez ID		57713	84456
HPRD ID		18853	11222
Ensembl ID		ENSG00000198879	ENSG00000198945
Uniprot IDs		Q5VUG0	Q96JM7
PDB IDs		1WJR	1WJQ 1WJS 3UT1 4FL6 4L59
Enriched GO Terms of Interacting Partners?
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