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RPS6KA1 and MTOR
Number of citations of the paper that reports this interaction (PubMedID
15905173
)
139
Data Source:
HPRD
(in vitro)
RPS6KA1
MTOR
Description
ribosomal protein S6 kinase A1
mechanistic target of rapamycin kinase
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Synapse
Golgi Membrane
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Mitochondrial Outer Membrane
Lysosome
Lysosomal Membrane
Endoplasmic Reticulum Membrane
Cytosol
Endomembrane System
Membrane
PML Body
Dendrite
TORC1 Complex
TORC2 Complex
Neuronal Cell Body
Phagocytic Vesicle
Glutamatergic Synapse
Postsynaptic Cytosol
Molecular Function
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Ribosomal Protein S6 Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Protein Serine Kinase Activity
RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding
RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding
RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding
TFIIIC-class Transcription Factor Complex Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Protein Kinase Binding
Protein Domain Specific Binding
Identical Protein Binding
Ribosome Binding
Translation Regulator Activity
Phosphoprotein Binding
Protein Serine Kinase Activity
Biological Process
Apoptotic Process
Cell Cycle
Signal Transduction
Chemical Synaptic Transmission
Peptidyl-serine Phosphorylation
Positive Regulation Of Cell Growth
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Translation In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Hepatocyte Proliferation
Positive Regulation Of Hepatic Stellate Cell Activation
Regulation Of Cell Growth
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
T-helper 1 Cell Lineage Commitment
Heart Morphogenesis
Heart Valve Morphogenesis
Regulation Of Glycogen Biosynthetic Process
Energy Reserve Metabolic Process
'de Novo' Pyrimidine Nucleobase Biosynthetic Process
Protein Phosphorylation
Lysosome Organization
Germ Cell Development
Brain Development
Cell Aging
Response To Nutrient
Long-term Memory
Regulation Of Cell Size
Visual Learning
Cellular Response To Starvation
Post-embryonic Development
Negative Regulation Of Autophagy
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Myotube Differentiation
Positive Regulation Of Neuron Projection Development
Positive Regulation Of Neuron Maturation
Negative Regulation Of Muscle Atrophy
Response To Activity
Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Spinal Cord Development
Protein Catabolic Process
Positive Regulation Of Actin Filament Polymerization
Negative Regulation Of Protein Ubiquitination
Ruffle Organization
Regulation Of Myelination
Response To Nutrient Levels
Cellular Response To Nutrient Levels
TOR Signaling
Regulation Of Fatty Acid Beta-oxidation
Regulation Of Response To Food
Activation Of Protein Kinase B Activity
Positive Regulation Of Phosphoprotein Phosphatase Activity
Response To Insulin
Regulation Of Actin Cytoskeleton Organization
Cellular Response To Amino Acid Starvation
Social Behavior
Multicellular Organism Growth
TORC1 Signaling
Wound Healing
Response To Cocaine
Regulation Of Circadian Rhythm
Regulation Of GTPase Activity
Response To Amino Acid
Anoikis
Response To Morphine
Regulation Of Carbohydrate Utilization
Positive Regulation Of Nitric Oxide Biosynthetic Process
Regulation Of Osteoclast Differentiation
Positive Regulation Of Translation
Negative Regulation Of Cell Size
Positive Regulation Of Transcription By RNA Polymerase III
Protein Autophosphorylation
Positive Regulation Of Lipid Biosynthetic Process
MRNA Stabilization
Rhythmic Process
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Voluntary Musculoskeletal Movement
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Keratinocyte Migration
Nucleus Localization
Positive Regulation Of Protein Kinase B Signaling
Cardiac Muscle Cell Development
Cardiac Muscle Contraction
Maternal Process Involved In Female Pregnancy
Positive Regulation Of Glial Cell Proliferation
Positive Regulation Of Dendritic Spine Development
Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Cellular Response To Amino Acid Stimulus
Cellular Response To Leucine
Cellular Response To Hypoxia
Regulation Of Brown Fat Cell Differentiation
Regulation Of Membrane Permeability
Regulation Of Translation At Synapse, Modulating Synaptic Transmission
Regulation Of Cellular Response To Heat
Positive Regulation Of Neuron Death
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells
Positive Regulation Of Eating Behavior
Positive Regulation Of Cholangiocyte Proliferation
Positive Regulation Of Sensory Perception Of Pain
Regulation Of Locomotor Rhythm
Negative Regulation Of Cholangiocyte Apoptotic Process
Positive Regulation Of Granulosa Cell Proliferation
Positive Regulation Of Skeletal Muscle Hypertrophy
Negative Regulation Of Iodide Transmembrane Transport
Positive Regulation Of Cytoplasmic Translational Initiation
Cellular Response To Leucine Starvation
Pathways
ERK/MAPK targets
CREB phosphorylation
Senescence-Associated Secretory Phenotype (SASP)
Senescence-Associated Secretory Phenotype (SASP)
Recycling pathway of L1
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
RSK activation
RSK activation
Gastrin-CREB signalling pathway via PKC and MAPK
PIP3 activates AKT signaling
Macroautophagy
MTOR signalling
mTORC1-mediated signalling
HSF1-dependent transactivation
Energy dependent regulation of mTOR by LKB1-AMPK
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Regulation of PTEN gene transcription
Amino acids regulate mTORC1
Drugs
Purvalanol A
Fostamatinib
Pimecrolimus
Sirolimus
Everolimus
Rimiducid
SF1126
XL765
Ridaforolimus
Temsirolimus
Fostamatinib
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Fasting plasma glucose (
31932636
)
Glucose homeostasis traits (
25524916
)
Lymphocyte counts (
32888494
)
Mean corpuscular volume (
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Rosacea symptom severity (
29771307
)
Triglyceride levels (
30108155
)
White blood cell count (
32888494
)
Beard thickness (
26926045
)
Body mass index (
25673413
)
Body mass index and type 2 diabetes (pairwise) (
33619380
)
Body shape index (
34021172
)
Corneal curvature (
24963161
)
Heel bone mineral density (
28869591
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Interacting Genes
93 interacting genes:
-
ACSBG2
ARHGEF11
ARHGEF12
ASCC3
ATXN3
BAD
CARHSP1
CCT4
CDKN1B
CEBPB
CFL1
CREB1
CREBBP
CXCL12
DDAH2
DEPTOR
DLC1
DLG4
EEF1D
EEF2K
ERBIN
ESR1
ETV1
FGFR1
FOS
GBP2
GMFB
GOPC
GORASP1
GORASP2
GRB2
GRID2IP
GSK3B
HTRA1
IGFBP2
L1CAM
LIMK2
LNX1
MAGI1
MAGI2
MAGI3
MAPK1
MAPK3
MAPT
MAST1
MAST2
METTL1
MITF
MPP1
MTOR
MXD1
NFKBIA
NR4A1
NR4A2
NR4A3
PARD3B
PDCD4
PDPK1
PDZD7
PDZK1
PDZRN3
PDZRN4
PHAX
POLDIP3
PPM1G
PPP1R3A
PPP1R9A
PTPN3
RABGGTB
RECK
RPTOR
SHANK3
SHROOM2
SLC9A3R2
SNTA1
SNTB1
SNTG2
SNX27
SRF
SRSF5
SYK
SYNJ2BP
TAMALIN
TOB2
TP53
TSC2
TTK
UBE2T
VCP
WHRN
YBX1
YWHAB
59 interacting genes:
AKT1
AKT1S1
AMBRA1
BCL2L1
C7orf25
CA6
CDC37
CFP
CLIP1
DCP2
EIF3F
EIF4EBP1
EIF4EBP2
EP300
ESR1
FBXO8
FKBP1A
FKBP8
GPHN
GSK3B
HRAS
IRS1
MAF1
MECR
MLST8
NPPB
NRAS
PA2G4
PDPK1
PIK3CD
PLD2
PPP2R2A
PREX1
PRKAA1
PRKCA
PRR5L
RHEB
RHEBL1
RICTOR
RPS6KA1
RPS6KB1
RPS6KB2
RPTOR
RRAGB
SEPTIN2
SKP2
SLC2A5
SLC45A1
SLC9A1
STAT3
SUMO1
TELO2
TERT
TRAF6
UBQLN1
UVRAG
WIPI2
YWHAQ
ZNRF2
Entrez ID
6195
2475
HPRD ID
03402
03134
Ensembl ID
ENSG00000117676
ENSG00000198793
Uniprot IDs
Q15418
P42345
PDB IDs
2WNT
2Z7Q
2Z7R
2Z7S
3RNY
3TEI
4H3P
4NIF
5CSF
5CSI
5CSJ
5CSN
5N7D
5N7F
5N7G
5V61
5V62
6TWY
1AUE
1FAP
1NSG
2FAP
2GAQ
2NPU
2RSE
3FAP
3JBZ
4DRH
4DRI
4DRJ
4FAP
4JSN
4JSP
4JSV
4JSX
4JT5
4JT6
5FLC
5GPG
5H64
5WBH
5WBU
5WBY
5ZCS
6BCU
6BCX
6M4U
6M4W
6SB0
6SB2
6ZWM
6ZWO
Enriched GO Terms of Interacting Partners
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