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MTOR and FKBP1A
Number of citations of the paper that reports this interaction (PubMedID
8662507
)
253
Data Source:
BioGRID
(affinity chromatography technology, pull down)
HPRD
(in vitro)
MTOR
FKBP1A
Description
mechanistic target of rapamycin kinase
FKBP prolyl isomerase 1A
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Mitochondrial Outer Membrane
Lysosome
Lysosomal Membrane
Endoplasmic Reticulum Membrane
Cytosol
Endomembrane System
Membrane
PML Body
Dendrite
TORC1 Complex
TORC2 Complex
Neuronal Cell Body
Phagocytic Vesicle
Glutamatergic Synapse
Postsynaptic Cytosol
Cytoplasm
Cytosol
Terminal Cisterna
Membrane
Sarcoplasmic Reticulum
Z Disc
Extrinsic Component Of Organelle Membrane
Cytoplasmic Side Of Membrane
Ryanodine Receptor Complex
Molecular Function
RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding
RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding
RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding
TFIIIC-class Transcription Factor Complex Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Protein Kinase Binding
Protein Domain Specific Binding
Identical Protein Binding
Ribosome Binding
Translation Regulator Activity
Phosphoprotein Binding
Protein Serine Kinase Activity
Peptidyl-prolyl Cis-trans Isomerase Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Macrolide Binding
FK506 Binding
Calcium Channel Inhibitor Activity
Type I Transforming Growth Factor Beta Receptor Binding
Transmembrane Transporter Binding
SMAD Binding
Activin Binding
Biological Process
Regulation Of Cell Growth
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
T-helper 1 Cell Lineage Commitment
Heart Morphogenesis
Heart Valve Morphogenesis
Regulation Of Glycogen Biosynthetic Process
Energy Reserve Metabolic Process
'de Novo' Pyrimidine Nucleobase Biosynthetic Process
Protein Phosphorylation
Lysosome Organization
Germ Cell Development
Brain Development
Cell Aging
Response To Nutrient
Long-term Memory
Regulation Of Cell Size
Visual Learning
Cellular Response To Starvation
Post-embryonic Development
Negative Regulation Of Autophagy
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Myotube Differentiation
Positive Regulation Of Neuron Projection Development
Positive Regulation Of Neuron Maturation
Negative Regulation Of Muscle Atrophy
Response To Activity
Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Spinal Cord Development
Protein Catabolic Process
Positive Regulation Of Actin Filament Polymerization
Negative Regulation Of Protein Ubiquitination
Ruffle Organization
Regulation Of Myelination
Response To Nutrient Levels
Cellular Response To Nutrient Levels
TOR Signaling
Regulation Of Fatty Acid Beta-oxidation
Regulation Of Response To Food
Activation Of Protein Kinase B Activity
Positive Regulation Of Phosphoprotein Phosphatase Activity
Response To Insulin
Regulation Of Actin Cytoskeleton Organization
Cellular Response To Amino Acid Starvation
Social Behavior
Multicellular Organism Growth
TORC1 Signaling
Wound Healing
Response To Cocaine
Regulation Of Circadian Rhythm
Regulation Of GTPase Activity
Response To Amino Acid
Anoikis
Response To Morphine
Regulation Of Carbohydrate Utilization
Positive Regulation Of Nitric Oxide Biosynthetic Process
Regulation Of Osteoclast Differentiation
Positive Regulation Of Translation
Negative Regulation Of Cell Size
Positive Regulation Of Transcription By RNA Polymerase III
Protein Autophosphorylation
Positive Regulation Of Lipid Biosynthetic Process
MRNA Stabilization
Rhythmic Process
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Voluntary Musculoskeletal Movement
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Keratinocyte Migration
Nucleus Localization
Positive Regulation Of Protein Kinase B Signaling
Cardiac Muscle Cell Development
Cardiac Muscle Contraction
Maternal Process Involved In Female Pregnancy
Positive Regulation Of Glial Cell Proliferation
Positive Regulation Of Dendritic Spine Development
Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Cellular Response To Amino Acid Stimulus
Cellular Response To Leucine
Cellular Response To Hypoxia
Regulation Of Brown Fat Cell Differentiation
Regulation Of Membrane Permeability
Regulation Of Translation At Synapse, Modulating Synaptic Transmission
Regulation Of Cellular Response To Heat
Positive Regulation Of Neuron Death
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells
Positive Regulation Of Eating Behavior
Positive Regulation Of Cholangiocyte Proliferation
Positive Regulation Of Sensory Perception Of Pain
Regulation Of Locomotor Rhythm
Negative Regulation Of Cholangiocyte Apoptotic Process
Positive Regulation Of Granulosa Cell Proliferation
Positive Regulation Of Skeletal Muscle Hypertrophy
Negative Regulation Of Iodide Transmembrane Transport
Positive Regulation Of Cytoplasmic Translational Initiation
Cellular Response To Leucine Starvation
Protein Peptidyl-prolyl Isomerization
Heart Morphogenesis
Protein Folding
'de Novo' Protein Folding
SMAD Protein Complex Assembly
Protein Maturation By Protein Folding
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Binding
Negative Regulation Of Phosphoprotein Phosphatase Activity
Regulation Of Protein Localization
Regulation Of Activin Receptor Signaling Pathway
Protein Refolding
T Cell Activation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Immune Response
Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Ventricular Cardiac Muscle Tissue Morphogenesis
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Heart Trabecula Formation
Chaperone-mediated Protein Folding
Calcium Ion Transmembrane Transport
Supramolecular Fiber Organization
Regulation Of Amyloid Precursor Protein Catabolic Process
Amyloid Fibril Formation
Pathways
PIP3 activates AKT signaling
Macroautophagy
MTOR signalling
mTORC1-mediated signalling
HSF1-dependent transactivation
Energy dependent regulation of mTOR by LKB1-AMPK
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Regulation of PTEN gene transcription
Amino acids regulate mTORC1
mTORC1-mediated signalling
Calcineurin activates NFAT
Calcineurin activates NFAT
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGFBR1 LBD Mutants in Cancer
Potential therapeutics for SARS
Drugs
Pimecrolimus
Sirolimus
Everolimus
Rimiducid
SF1126
XL765
Ridaforolimus
Temsirolimus
Fostamatinib
Pimecrolimus
Tacrolimus
Sirolimus
(3R)-4-(p-toluenesulfonyl)-1,4-thiazane-3-carboxylicacid-L-phenylalanine ethyl ester
{3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid
Gpi-1046
Methyl Methylsulfinylmethyl Sulfide
FKB-001
Heptyl glucoside
L-709,587
(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine
4-hydroxybutan-2-one
GPI-1485
Myristic acid
(21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE
Dorsomorphin
Diseases
GWAS
Beard thickness (
26926045
)
Body mass index (
25673413
)
Body mass index and type 2 diabetes (pairwise) (
33619380
)
Body shape index (
34021172
)
Corneal curvature (
24963161
)
Heel bone mineral density (
28869591
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Estimated glomerular filtration rate (
31152163
)
Interacting Genes
59 interacting genes:
AKT1
AKT1S1
AMBRA1
BCL2L1
C7orf25
CA6
CDC37
CFP
CLIP1
DCP2
EIF3F
EIF4EBP1
EIF4EBP2
EP300
ESR1
FBXO8
FKBP1A
FKBP8
GPHN
GSK3B
HRAS
IRS1
MAF1
MECR
MLST8
NPPB
NRAS
PA2G4
PDPK1
PIK3CD
PLD2
PPP2R2A
PREX1
PRKAA1
PRKCA
PRR5L
RHEB
RHEBL1
RICTOR
RPS6KA1
RPS6KB1
RPS6KB2
RPTOR
RRAGB
SEPTIN2
SKP2
SLC2A5
SLC45A1
SLC9A1
STAT3
SUMO1
TELO2
TERT
TRAF6
UBQLN1
UVRAG
WIPI2
YWHAQ
ZNRF2
31 interacting genes:
ABI2
ACVR1B
ACVRL1
AHSP
APP
BARD1
BMPR1A
CDC42
DHFR
ERBB2
ERBB3
ERBB4
FKBP4
FOXJ1
GLMN
HSP90AA1
ITPR1
MAPT
MDM2
MID1
MTOR
NLGN3
PPP3CA
RYR1
RYR3
SF3B4
TGFB1
TGFB1I1
TGFBR1
TRPC3
YY1
Entrez ID
2475
2280
HPRD ID
03134
01741
Ensembl ID
ENSG00000198793
ENSG00000088832
Uniprot IDs
P42345
A0A087WTS4
P62942
Q0VDC6
PDB IDs
1AUE
1FAP
1NSG
2FAP
2GAQ
2NPU
2RSE
3FAP
3JBZ
4DRH
4DRI
4DRJ
4FAP
4JSN
4JSP
4JSV
4JSX
4JT5
4JT6
5FLC
5GPG
5H64
5WBH
5WBU
5WBY
5ZCS
6BCU
6BCX
6M4U
6M4W
6SB0
6SB2
6ZWM
6ZWO
1A7X
1B6C
1BKF
1BL4
1D6O
1D7H
1D7I
1D7J
1EYM
1F40
1FAP
1FKB
1FKD
1FKF
1FKG
1FKH
1FKI
1FKJ
1FKR
1FKS
1FKT
1J4H
1J4I
1J4R
1NSG
1QPF
1QPL
2DG3
2DG4
2DG9
2FAP
2FKE
2ND5
2PPN
2PPO
2PPP
2RSE
3FAP
3H9R
3MDY
4DH0
4FAP
4IPX
4N19
4ODP
4ODQ
4ODR
5I7P
5I7Q
6I1S
6M4U
6OQA
6VCU
Enriched GO Terms of Interacting Partners
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