RPS3A and EDEM2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RPS3A	EDEM2
Description		ribosomal protein S3A	ER degradation enhancing alpha-mannosidase like protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Focal Adhesion Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Extracellular Exosome Ribonucleoprotein Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding MRNA 5'-UTR Binding	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding
	Biological Process	Cytoplasmic Translation Translation Translational Initiation Cell Differentiation Negative Regulation Of Apoptotic Process	Carbohydrate Metabolic Process Response To Unfolded Protein Viral Protein Processing Trimming Of Terminal Mannose On B Branch Trimming Of Terminal Mannose On C Branch Trimming Of First Mannose On A Branch Trimming Of Second Mannose On A Branch Ubiquitin-dependent Glycoprotein ERAD Pathway Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Mannose Trimming Involved In Glycoprotein ERAD Pathway
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	ER Quality Control Compartment (ERQC) Maturation of spike protein
Drugs
Diseases
GWAS		HDL cholesterol ( 20686565)	Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Blood protein levels ( 28240269) Body shape index ( 34021172) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 30275531) Hemostatic factors and hematological phenotypes ( 22443383) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Offspring birth weight ( 31043758) Protein C levels ( 28082259 20802025) Prothrombin time ( 22703881) QRS complex (Cornell) ( 27659466) Serum alkaline phosphatase levels ( 33547301) Venous thromboembolism ( 31676865) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		20 interacting genes: ATF7IP C11orf49 CCDC50 CHN1 CREB3 DDIT3 DUX4 EDEM2 FANCC HGS HSP90AA1 LINC01232 NEDD4 OGT PARP1 SAP18 SOD2 TOE1 UBE2I VDAC2	2 interacting genes: RPS3A TRPC4AP
Entrez ID		6189	55741
HPRD ID		01606	09841
Ensembl ID		ENSG00000145425	ENSG00000088298
Uniprot IDs		B7Z3M5 P61247	Q9BV94
PDB IDs		4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBD 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I
Enriched GO Terms of Interacting Partners?
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