ROBO2 and SLIT3

Number of citations of the paper that reports this interaction (PubMedID 11754167)
91

Data Source:
HPRD (in vivo, in vitro)

		ROBO2	SLIT3
Description		roundabout guidance receptor 2	slit guidance ligand 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane Axolemma Extracellular Exosome	Extracellular Space Mitochondrion
	Molecular Function	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding	Calcium Ion Binding Heparin Binding Roundabout Binding
	Biological Process	Metanephros Development Ureteric Bud Development Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Spinal Cord Development Olfactory Bulb Interneuron Development Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Positive Regulation Of Notch Signaling Pathway Involved In Heart Induction Aorta Development Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis	Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Axon Guidance Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Cell Growth Cellular Response To Hormone Stimulus Roundabout Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Response To Cortisol Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway
Pathways		Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs ROBO receptors bind AKAP5	Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs
Diseases
GWAS		Bell's palsy ( 33602968) Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Expressive vocabulary in infants ( 25226531) Familial lung adenocarcinoma ( 29924316) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Hand grip strength ( 29691431) Hip circumference ( 28552196) LDL cholesterol levels in HIV infection ( 33109212) Left-handedness ( 32989287) Metabolite levels ( 23823483) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Morning person ( 30696823) Periodontitis (PAL4Q3) ( 24024966) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to ketamine in bipolar disorder or major depression (dissociation effects) ( 30552317) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30297969)	Atrial fibrillation ( 30061737) Bipolar disorder x sex interaction ( 34099189) Body mass index ( 31217584) Circulating leptin levels in high cardiovascular risk ( 31766143) Circulating leptin levels x sex interaction in high cardiovascular risk ( 31766143) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Gut microbiota (functional units) ( 27694959) Hallux valgus ( 32131869) Height ( 28552196 20881960 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory skin disease ( 25574825) Menarche (age at onset) ( 25231870) Non-word reading ( 30741946) Total cholesterol levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Treatment resistant depression ( 30468137)
Interacting Genes		18 interacting genes: BNIP3L CENPU CPE GPR152 HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TMEM237 TRIM13 UBQLN4	11 interacting genes: CAPN1 CASP9 HRH2 IGSF8 KHDRBS3 MAML1 MAPK9 MGAT4B ROBO2 RXRB SQSTM1
Entrez ID		6092	6586
HPRD ID		11895	04775
Ensembl ID		ENSG00000185008	ENSG00000184347
Uniprot IDs		Q9HCK4	O75094
PDB IDs		1UEM 1UJT 2EDJ 5NOI 6I9S 6IAA
Enriched GO Terms of Interacting Partners?
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