SLIT3 and IGSF8

		SLIT3	IGSF8
Description		slit guidance ligand 3	immunoglobulin superfamily member 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Mitochondrion	Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Calcium Ion Binding Heparin Binding Roundabout Binding	Protein Binding
	Biological Process	Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Axon Guidance Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Cell Growth Cellular Response To Hormone Stimulus Roundabout Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Response To Cortisol Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway	Single Fertilization Nervous System Development Skeletal Muscle Tissue Development Cell Motility
Pathways		Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737) Bipolar disorder x sex interaction ( 34099189) Body mass index ( 31217584) Circulating leptin levels in high cardiovascular risk ( 31766143) Circulating leptin levels x sex interaction in high cardiovascular risk ( 31766143) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Gut microbiota (functional units) ( 27694959) Hallux valgus ( 32131869) Height ( 28552196 20881960 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory skin disease ( 25574825) Menarche (age at onset) ( 25231870) Non-word reading ( 30741946) Total cholesterol levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Treatment resistant depression ( 30468137)
Interacting Genes		11 interacting genes: CAPN1 CASP9 HRH2 IGSF8 KHDRBS3 MAML1 MAPK9 MGAT4B ROBO2 RXRB SQSTM1	18 interacting genes: A2M CD47 CD81 CD82 CD9 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-4 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP5-7 SLIT3 TGM1
Entrez ID		6586	93185
HPRD ID		04775	09438
Ensembl ID		ENSG00000184347	ENSG00000162729
Uniprot IDs		O75094	Q969P0
PDB IDs
Enriched GO Terms of Interacting Partners?
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