RFX1 and NFIC

Number of citations of the paper that reports this interaction (PubMedID 12624117)
6

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		RFX1	NFIC
Description		regulatory factor X1	nuclear factor I C
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Intracellular Membrane-bounded Organelle	Chromatin Fibrillar Center Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Immune Response	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways			RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS			Alzheimer's disease (APOE e4 interaction) ( 28183528) Apolipoprotein A1 levels ( 32203549) Automobile speeding propensity ( 30643258) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103 31562340) High light scatter reticulocyte count ( 32888494) Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Monocyte count ( 32888494) Nevus count or cutaneous melanoma ( 30429480) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum urate levels in chronic kidney disease ( 30181573) Weight ( 28552196) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		15 interacting genes: ABL1 ADD1 HIVEP2 HMGB1 MAGED1 NFIB NFIC NFIX PRKACA RFX2 RFX3 SMAD1 SMAD4 SMAD9 TADA3	26 interacting genes: CBLC CREBBP DACH1 EPHA2 ERGIC1 FBXO7 GLIS1 GLIS2 GLRX LATS2 LLPH MAP2K3 MAPK14 MYC NFIB NSD3 RELA RFX1 SOX3 TEAD2 TH TKTL2 TLX1 TPD52L3 ZCCHC14 ZKSCAN7
Entrez ID		5989	4782
HPRD ID		02476	09009
Ensembl ID		ENSG00000132005	ENSG00000141905
Uniprot IDs		P22670	B7Z4T6 P08651
PDB IDs		1DP7
Enriched GO Terms of Interacting Partners?
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