RFC3 and KHDRBS3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RFC3	KHDRBS3
Description		replication factor C subunit 3	KH RNA binding domain containing, signal transduction associated 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Ctf18 RFC-like Complex	Nucleus Nucleoplasm Protein-containing Complex
	Molecular Function	DNA Binding DNA Clamp Loader Activity Protein Binding ATP-dependent Activity, Acting On DNA Single-stranded DNA Helicase Activity	RNA Binding MRNA Binding Protein Binding SH3 Domain Binding Protein Domain Specific Binding Identical Protein Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair DNA Duplex Unwinding Response To Organophosphorus Positive Regulation Of DNA-directed DNA Polymerase Activity	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint	PTK6 Regulates Proteins Involved in RNA Processing
Drugs
Diseases
GWAS		Alzheimer's disease ( 20061627) Colorectal cancer or advanced adenoma ( 30510241) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Obesity-related traits ( 23251661)	Chronotype ( 30696823) Colorectal cancer ( 34062886) Disease progression in age-related macular degeneration ( 29346644) Polycystic ovary syndrome ( 25574032) Squamous cell lung carcinoma ( 28604730) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		13 interacting genes: ANKRD40 ARFGAP1 CHTF8 INCA1 KHDRBS2 KHDRBS3 MESD PCNA PICK1 PTEN RAD17 RFC1 RFC4	57 interacting genes: AQP1 BAHD1 CACNA1A CCDC187 CCDC33 CNNM3 DMRT3 DOCK2 FBXO7 FUS FXR1 HBZ HNRNPC HNRNPK INPP5D KHDRBS1 KHDRBS2 LMNTD2 LNX1 MARK4 MYPOP NCOA5 NELFB NUDT18 OGT PCDHB14 PPP1R13B PRMT1 PRPF31 PRR3 PSMA1 PSMF1 PTBP2 RASAL3 RASD1 RBBP6 RBM3 RBM7 RBMX RBMY1A1 RFC3 RPH3AL SGSM2 SIAH1 SLIT3 SNRPC SNX18 SRSF9 TSGA10IP TYK2 U2AF2 YTHDC1 ZNF326 ZNF408 ZNF575 ZNF580 ZNF688
Entrez ID		5983	10656
HPRD ID		02676	10007
Ensembl ID		ENSG00000133119	ENSG00000131773
Uniprot IDs		A0A024RDQ8 P40938	O75525
PDB IDs		6VVO	5EL3 5ELR 5ELS 5ELT 5EMO
Enriched GO Terms of Interacting Partners?
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