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REL and SIX1
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
REL
SIX1
Description
REL proto-oncogene, NF-kB subunit
SIX homeobox 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytosol
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytoplasm
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Gene Expression
Negative Regulation Of Interferon-beta Production
Cellular Response To Stress
Response To Cytokine
NIK/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Neuron Death
Negative Regulation Of Transcription By RNA Polymerase II
Ureteric Bud Development
Branching Involved In Ureteric Bud Morphogenesis
Organ Induction
Kidney Development
Outflow Tract Morphogenesis
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Pattern Specification Process
Skeletal Muscle Tissue Development
Sensory Perception Of Sound
Regulation Of Synaptic Assembly At Neuromuscular Junction
Regulation Of Skeletal Muscle Satellite Cell Proliferation
Regulation Of Skeletal Muscle Cell Proliferation
Facial Nerve Morphogenesis
Epithelial Cell Differentiation
Thyroid Gland Development
Olfactory Placode Formation
Regulation Of Protein Localization
Protein Localization To Nucleus
Aorta Morphogenesis
Inner Ear Morphogenesis
Middle Ear Morphogenesis
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Thymus Development
Neuron Fate Specification
Generation Of Neurons
Embryonic Cranial Skeleton Morphogenesis
Embryonic Skeletal System Morphogenesis
Skeletal Muscle Fiber Development
Inner Ear Development
Regulation Of Epithelial Cell Proliferation
Myoblast Migration
Pharyngeal System Development
Myotome Development
Fungiform Papilla Morphogenesis
Trigeminal Ganglion Development
Otic Vesicle Development
Metanephric Mesenchyme Development
Regulation Of Branch Elongation Involved In Ureteric Bud Branching
Positive Regulation Of Ureteric Bud Formation
Mesonephric Tubule Formation
Ureter Smooth Muscle Cell Differentiation
Positive Regulation Of Secondary Heart Field Cardioblast Proliferation
Cochlea Morphogenesis
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Positive Regulation Of Brown Fat Cell Differentiation
Cellular Response To 3,3',5-triiodo-L-thyronine
Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development
Regulation Of Skeletal Muscle Cell Differentiation
Pathways
Activation of NF-kappaB in B cells
Drugs
Diseases
GWAS
Celiac disease (
20190752
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Crohn's disease (
22412388
21102463
)
Erectile dysfunction (
30583798
)
Hodgkin's lymphoma (
21037568
24920014
)
Inflammatory bowel disease (
23128233
)
Psoriasis (
25903422
20953190
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Psoriatic arthritis (
26626624
22170493
)
Rheumatoid arthritis (
30423114
23143596
24390342
20453842
19503088
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Ulcerative colitis (
20228799
)
Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease (
29631575
)
Glaucoma (
31959993
)
Glaucoma (multi-trait analysis) (
31959993
)
Glaucoma (primary open-angle) (
22419738
29891935
22570617
)
Gut microbiota (bacterial taxa) (
27723756
)
Height (
31562340
)
Hip circumference adjusted for BMI (
34021172
)
Optic disc size (
31809533
)
Optic nerve measurement (rim area) (
20395239
)
Prostate cancer (
25217961
)
Refractive error (
32231278
)
Vertical cup-disc ratio (
20548946
25241763
)
Interacting Genes
326 interacting genes:
A1CF
AAAS
ACBD4
ACOT12
ACOT8
ACTN3
ADRB2
ADSL
AGPAT4
AKT2
ALOX5
AQP1
AR
ARFIP2
ARIH2
ARL16
ARMC7
ARNT2
ASAP3
ASMTL
ATG9A
ATP6V0D2
ATP6V1C2
ATPAF2
ATXN1
BANP
BARHL2
BBS4
BCL2L15
BCL6
BID
BMF
C11orf68
C12orf75
C14orf119
C1orf109
C1orf50
C1orf56
C1orf74
C9orf72
CABP5
CACNA1S
CALM1
CCNC
CCNE1
CCNJL
CDK18
CDKN1A
CDKN2C
CDKN2D
CDR2L
CENPX
CEP19
CFAP206
CGGBP1
CHAF1A
CHCHD2
CHIC2
CIB3
CINP
CKS1B
CLIC4
CLIP1
COL20A1
COL8A1
CPNE2
CPNE7
CPSF1
CSNK2A1
CTNNA3
CTNNBIP1
CXCL14
CYB5R2
DAAM2
DDX6
DEF6
DGCR6
DHPS
DMRT3
DNTT
DPF2
DYNC1LI1
EFHC1
EHHADH
EIF3A
EIF3D
EIF4A3
EIF4E2
EIF4EBP1
EIF5A
EIF5A2
ELF1
EMD
EML2
EP300
EPHB6
EPM2AIP1
ESRRA
ESRRG
EXOC6B
EXOSC1
EXOSC5
EXOSC8
FAAP20
FAM90A1
FHIT
FHL2
FKBP1B
FLAD1
FLNA
FNDC11
FNDC3B
FOXO4
FUT11
GADD45G
GLRX3
GLYCTK
GPKOW
GRAP
GRB2
GTF2B
HAT1
HDAC7
HIP1
HLA-DOA
HNRNPF
HNRNPLL
HSD17B14
HSPA4
HSPA8
HSPB7
IL36RN
KCTD6
KCTD7
KIAA0100
KLHL32
KLHL40
KLHL42
KRTAP9-4
L3MBTL2
LASP1
LENG1
LGALS14
LMO1
LMO2
LNPEP
LSM2
MAD2L2
MAGOHB
MAP3K7CL
MAP3K8
MAPK8
MAPRE3
MB21D2
MBD3
MEMO1
MID2
MIEN1
MIPOL1
MLIP
MMP2
MOGS
MORF4L1
MORF4L2
MRPL10
MSRB3
MTPN
MTURN
MVP
MXD1
MYO15B
NABP1
NAGK
NCK2
NDE1
NDUFAF3
NECAP1
NEDD9
NEIL2
NEUROG3
NFE2L2
NFKB1
NFKB2
NFKBIA
NFKBIB
NFKBIE
NGB
NKRF
NME7
NMRK1
NOL9
NOTCH1
NOXA1
NR2C2AP
NUCB1
NUDT10
NUDT14
NXT2
OAZ3
OSGIN1
OSTF1
OTUB2
OTUD4
PADI3
PAK1IP1
PARVG
PATE1
PCYT2
PELI2
PGAP6
PICK1
PIH1D2
PLCB4
PLEKHN1
PM20D2
POLE2
POLR1A
POLR2L
POP5
PPP4C
PRDM10
PRKAA2
PRKAB2
PRKN
PRPF31
PSMA1
PSMA4
PSMB8
PSORS1C2
PTGER3
PTK6
QARS1
R3HDM2
RAB11FIP5
RAB29
RAB41
RABIF
RAD23A
RAD51D
RASSF5
RBM39
RECK
RELA
REXO1L6P
RIPPLY1
RNF213
RNF6
RSPH14
RTL8C
RUNX1T1
S100A1
SAMD11
SAT1
SCNM1
SDCBP
SEC14L4
SEC31A
SEPTIN7
SERTAD2
SHC3
SIN3A
SIX1
SLC39A13
SLC41A3
SLC6A12
SMG9
SNRNP25
SP1
SPATC1L
SPG21
SPRY1
SRF
STAMBPL1
STK16
SULT2B1
SUOX
SZT2
TBC1D21
TBC1D22B
TBP
TCL1A
TCP11L1
TDO2
THOC1
TLE5
TLX3
TMEM165
TMEM268
TNIP2
TNS2
TRAPPC2L
TRAPPC6A
TRIM27
TRIM68
TRIM74
TSC22D3
TSEN15
TSPOAP1
TSSC4
TSSK3
TSTD2
TTC19
TTC21A
TXNL4B
UBASH3A
UBASH3B
UBE2D4
UBE2K
UBE2Z
UBXN7
VPS25
WNK3
YARS1
YJU2
ZBED8
ZBTB16
ZDHHC24
ZIC1
ZNF417
ZNF446
ZNF550
ZNF564
ZNF572
ZNF688
ZNF76
ZNF765
15 interacting genes:
CCDC85B
DACH1
EYA1
EYA2
EYA3
EYA4
H2AP
MDFI
PLEKHG4
POU6F2
REL
TLE1
TLE3
TLE5
VTN
Entrez ID
5966
6495
HPRD ID
01286
03125
Ensembl ID
ENSG00000162924
ENSG00000126778
Uniprot IDs
Q04864
Q15475
PDB IDs
4EGC
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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