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RASA1 and NRAS
Number of citations of the paper that reports this interaction (PubMedID
24412244
)
2
Data Source:
BioGRID
(two hybrid)
RASA1
NRAS
Description
RAS p21 protein activator 1
NRAS proto-oncogene, GTPase
Image
GO Annotations
Cellular Component
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
Golgi Membrane
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Membrane
Extracellular Exosome
Tertiary Granule Membrane
Molecular Function
Phosphotyrosine Residue Binding
GTPase Activity
GTPase Activator Activity
Signaling Receptor Binding
Protein Binding
Potassium Channel Inhibitor Activity
GTPase Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
GDP Binding
Protein-containing Complex Binding
Biological Process
Mitotic Cytokinesis
Vasculogenesis
Negative Regulation Of Cell-matrix Adhesion
Negative Regulation Of Cell Adhesion
Signal Transduction
Regulation Of Cell Shape
Regulation Of Actin Filament Polymerization
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Negative Regulation Of Ras Protein Signal Transduction
Ephrin Receptor Signaling Pathway
Blood Vessel Morphogenesis
Regulation Of RNA Metabolic Process
MAPK Cascade
Positive Regulation Of Endothelial Cell Proliferation
Ras Protein Signal Transduction
Pathways
Downstream signal transduction
EPHB-mediated forward signaling
EPHB-mediated forward signaling
VEGFR2 mediated cell proliferation
Regulation of RAS by GAPs
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
SOS-mediated signalling
Activation of RAS in B cells
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
Signalling to RAS
p38MAPK events
p38MAPK events
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
FCERI mediated MAPK activation
NCAM signaling for neurite out-growth
Ras activation upon Ca2+ influx through NMDA receptor
VEGFR2 mediated cell proliferation
CD209 (DC-SIGN) signaling
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Regulation of RAS by GAPs
RAF activation
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
RAS signaling downstream of NF1 loss-of-function variants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Insulin receptor signalling cascade
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAS signaling
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
Activated NTRK2 signals through RAS
Erythropoietin activates RAS
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK3 signals through RAS
FLT3 Signaling
Constitutive Signaling by Overexpressed ERBB2
Estrogen-stimulated signaling through PRKCZ
RAS processing
RAS GTPase cycle mutants
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Drugs
Diseases
GWAS
Chronotype (
30696823
)
Macular thickness (
30535121
)
Major depressive disorder (
23377640
)
Openness (
21173776
)
Prostate cancer aggressiveness (
25939597
)
Type 2 diabetes (
30297969
)
Adult body size (
32376654
)
Autism (
24189344
)
Interacting Genes
96 interacting genes:
ABL1
AFAP1L2
ALK
ANXA6
APC
APP
AR
ARHGAP1
ARHGAP5
AURKA
AURKB
BBS10
BCL10
BCR
BIRC5
BMPR1A
BUB1
CASP3
CASP7
CAV2
CD5
CDKN2A
CSF1R
CSK
DCC
DLC1
DNAJA3
DOK1
DOK2
DOK4
EGFR
EIF1
EPHA2
EPHB2
EPHB3
ERBB2
ERBB3
ERBB4
EZH2
FES
FGFR1
G3BP1
GAB1
GMCL1
GRB2
HCK
HRAS
HSPD1
HTT
IGF1R
INSR
KDR
KHDRBS1
KIT
LCK
LYN
MAGI1
MAP4K4
MET
MLH3
NCK1
NRAS
NTRK1
OLIG1
PAG1
PDE6D
PDGFRB
PIK3R1
PMS2
PTK2B
PTPRC
PTPRJ
PXN
RAB5A
RACK1
RAP1A
RB1
SERPINA4
SHC1
SLC9A2
SMAD2
SOCS3
SPSB1
SRC
STAU1
STK11
SYK
SYN1
TRMT2A
WWP1
WWP2
XRCC6
YES1
ZAP70
ZNF366
ZNF579
49 interacting genes:
ACVR1
AKT1
ALDOB
AOPEP
ARAF
ARHGAP4
BCL2
CCDC180
CORO2A
CYLC2
DNAJB1
EEF1A1
FANCC
FBP2
FRAT2
HEMGN
HRAS
IRS2
ITCH
LEF1
LZTR1
MAPK3
MAPKAP1
MTOR
PIK3CA
PIK3CG
PLCE1
PPP2CB
RACGAP1
RAF1
RAP1GDS1
RASA1
RASGRP2
RASSF5
RGL2
RGL3
RIN1
RPS20
SFRP4
SHOC2
SMAD1
SMAD4
SMURF2
SRI
STX17
TDRD7
TRMO
WDR76
XPA
Entrez ID
5921
4893
HPRD ID
00745
01273
Ensembl ID
ENSG00000145715
ENSG00000213281
Uniprot IDs
P20936
Q59GK3
P01111
Q5U091
PDB IDs
1WER
1WQ1
2GQI
2GSB
2J05
2J06
2M51
4FSS
6PXB
6PXC
6WAX
6WAY
2N9C
3CON
5UHV
6E6H
6MPP
6ULI
6ULK
6ULN
6ULR
6UON
6WGH
6ZIO
6ZIR
6ZIZ
Enriched GO Terms of Interacting Partners
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