RAPSN and KLHL8

Number of citations of the paper that reports this interaction (PubMedID 19158078)
9

Data Source:
BioGRID (enzymatic study)

		RAPSN	KLHL8
Description		receptor associated protein of the synapse	kelch like family member 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Centrosome Cytosol Plasma Membrane Neuromuscular Junction Postsynaptic Specialization Membrane	Nucleoplasm Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Acetylcholine Receptor Binding Ionotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Metal Ion Binding
	Biological Process	Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuromuscular Synaptic Transmission Regulation Of Postsynaptic Membrane Organization Establishment Of Protein Localization To Postsynaptic Membrane	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159) Diastolic blood pressure ( 28739976 27618452) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fruit consumption ( 32066663) General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 33627673) Global electrical heterogeneity phenotypes ( 29622589) Height ( 28552196) Intraocular pressure ( 29617998 25173106 29235454) Lacunar stroke ( 33773637) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mood instability ( 31168069) Neuroticism ( 29255261) Red cell distribution width ( 32888494) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Systolic blood pressure ( 28739976 27618452) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 29403010)	Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 33547301 29403010 33339817) Bulimia nervosa ( 23568457) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 28334899) Rosacea symptom severity ( 29771307) Total cholesterol levels ( 30275531) Triglyceride levels ( 28334899 29403010 33339817) Triglycerides ( 24097068 25961943 20686565)
Interacting Genes		8 interacting genes: CHRNB1 DAG1 GRB2 KHDRBS1 KLHL8 MUSK TRIM54 UBE2Z	13 interacting genes: ARMC9 ATXN1 CA8 COIL MAPK9 PNMT PPM1F RAPSN RLBP1 SULT2B1 TEX101 TP53I13 USP7
Entrez ID		5913	57563
HPRD ID		03353	13928
Ensembl ID		ENSG00000165917	ENSG00000145332
Uniprot IDs		A0A0S2Z4A2 A0A0S2Z4A6 A0A0S2Z4F8 A0A0S2Z4M9 Q13702	B3KY78 Q68DU9 Q7Z330 Q9P2G9
PDB IDs
Enriched GO Terms of Interacting Partners?
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