RAD51 and CST6

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		RAD51	CST6
Description		RAD51 recombinase	cystatin E/M
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Chromatin Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Microtubule Organizing Center PML Body Protein-containing Complex Site Of Double-strand Break Perinuclear Region Of Cytoplasm	Cornified Envelope Extracellular Exosome
	Molecular Function	DNA Strand Exchange Activity Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding ATP-dependent Activity, Acting On DNA Single-stranded DNA Helicase Activity Enzyme Binding Identical Protein Binding DNA Polymerase Binding	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly Regulation Of Protein Phosphorylation DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination Mitotic Recombination Cellular Response To DNA Damage Stimulus Reciprocal Meiotic Recombination Response To Xenobiotic Stimulus Response To Toxic Substance Response To X-ray Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Replication Fork Processing Interstrand Cross-link Repair Strand Invasion Positive Regulation Of DNA Ligation Meiotic Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Camptothecin Response To Glucoside Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic Recombination-dependent Replication Fork Processing	Epidermis Development Anatomical Structure Morphogenesis Negative Regulation Of Endopeptidase Activity
Pathways		HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Transcriptional Regulation by E2F6 Meiotic recombination Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Amuvatinib
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278)	Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Blood protein levels ( 30072576 29875488) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Height ( 31562340) Serum uric acid levels ( 32514006) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		95 interacting genes: - ABL1 AGO2 ATM ATRX BARD1 BCCIP BCR BLM BRCA1 BRCA2 C1orf112 CASP3 CASP7 CCND1 CDH13 CHD3 CHEK1 CSNK2A1 CSNK2B CST6 CTCF DDB2 DMC1 DNAJA3 DYRK1A ENAH EP400 ERCC2 ERCC5 EVL FANCD2 FANCI FBH1 FIGNL1 HID1 HNRNPC HSP90AA1 IL24 IRS1 ITIH5 MAPK8IP3 MDC1 MMS22L MND1 MSH4 NBN NCL NELFB NXF1 PALB2 PARPBP PCSK1N PDS5B PFN1 PLK1 POLA1 RAD18 RAD51AP1 RAD51AP2 RAD51B RAD51C RAD52 RAD54B RAD54L RECQL5 RELA RFWD3 RPA1 RPA2 RPA3 SEM1 SFR1 SIRT2 ST14 SUMO1 SUMO2 SWSAP1 TFF1 TP53 TP53BP1 UBE2I UCHL3 UGDH UHRF2 UMPS USP10 VASP VIM WDR48 WRN XPO1 XRCC2 XRCC3 ZDHHC17	7 interacting genes: BCAR3 GSK3B NOTCH2 PALB2 RAD51 TGFB1 YIF1A
Entrez ID		5888	1474
HPRD ID		01557	03535
Ensembl ID		ENSG00000051180	ENSG00000175315
Uniprot IDs		Q06609	Q15828
PDB IDs		1B22 1N0W 5H1B 5H1C 5JZC 5NP7 5NWL 7C9A	4N6L 4N6M 4N6N 4N6O 6FK0
Enriched GO Terms of Interacting Partners?
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