RAD51 and CDH13

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		RAD51	CDH13
Description		RAD51 recombinase	cadherin 13
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Chromatin Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Microtubule Organizing Center PML Body Protein-containing Complex Site Of Double-strand Break Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Caveola Focal Adhesion External Side Of Plasma Membrane Catenin Complex Anchored Component Of Membrane Neuron Projection Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome GABA-ergic Synapse
	Molecular Function	DNA Strand Exchange Activity Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding ATP-dependent Activity, Acting On DNA Single-stranded DNA Helicase Activity Enzyme Binding Identical Protein Binding DNA Polymerase Binding	Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Protein Homodimerization Activity Cadherin Binding Adiponectin Binding Lipoprotein Particle Binding
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly Regulation Of Protein Phosphorylation DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination Mitotic Recombination Cellular Response To DNA Damage Stimulus Reciprocal Meiotic Recombination Response To Xenobiotic Stimulus Response To Toxic Substance Response To X-ray Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Replication Fork Processing Interstrand Cross-link Repair Strand Invasion Positive Regulation Of DNA Ligation Meiotic Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Camptothecin Response To Glucoside Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic Recombination-dependent Replication Fork Processing	Mitotic Cell Cycle Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Rac Protein Signal Transduction Lamellipodium Assembly Regulation Of Endocytosis Positive Regulation Of Cell Migration Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Endothelial Cell Migration Keratinocyte Proliferation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Positive Chemotaxis Localization Within Membrane Low-density Lipoprotein Particle Mediated Signaling Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Pathways		HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Transcriptional Regulation by E2F6 Meiotic recombination Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Adherens junctions interactions
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Amuvatinib
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278)	Adiponectin levels ( 20876611 22479202 22065538 31178129 20887962 21771975 24105470) Adolescent idiopathic scoliosis ( 31417091 30395268) Adult body size ( 32376654) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145) Alcohol consumption (heavy vs. light/non-drinkers) ( 27911795) Anthracycline-induced cardiotoxicity in early breast cancer ( 32378780) Attention deficit hyperactivity disorder ( 18839057) Bipolar disorder ( 31043756) Blood pressure ( 17903302) Bortezomib-induced peripheral neuropathy in multiple myeloma ( 28317148) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 30104761 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Crohn's disease ( 28067908) D-dimer levels ( 21502573) Daytime sleep phenotypes ( 27126917) Declining hemoglobin trajectory in blood donors ( 33491795) Dental caries (decayed, missing and filled teeth) ( 31533690) Depression (quantitative trait) ( 20800221) Diastolic blood pressure ( 27841878 31170924 30578418) Dimensional psychopathology (Arousal) ( 29496196) Dimensional psychopathology (Negative) ( 29496196) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erectile dysfunction ( 30583798) Feeling hurt ( 29500382) Feeling tense ( 29500382) Fish- and plant-related diet ( 32066663) Gait speed in old age ( 28077804) General risk tolerance (MTAG) ( 30643258) Glucose homeostasis traits ( 25524916) Gut microbiota relative abundance (Blautia) ( 33208821) Gut microbiota relative abundance (Prevotella) ( 33208821) Height ( 20189936) Hippocampal volume ( 31530798) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Hypertension ( 19304780) Hypothyroidism ( 27182965) IgE levels in asthmatics (D.f. specific) ( 23967269) Leukoderma in response to rhododendrol ( 32558222) Maximal oxygen uptake response ( 25729143) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) Oily fish consumption ( 32066663) Periodontitis (Mean PAL) ( 24024966) Pork consumption ( 32066663) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 32439900) Precuneus cortex volume ( 31530798) Pulse pressure ( 28135244 27841878 28739976 30578418) Rapid automised naming of digits ( 30741946) Refractive astigmatism ( 30306274) Response to amphetamines ( 22952603) Response to antipsychotic treatment ( 20195266) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Response to fenofibrate (adiponectin levels) ( 23149075) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Schizophrenia ( 23358160) Seasonality and depression ( 30217971) Short-term memory (digit-span task) ( 30741946)
Interacting Genes		95 interacting genes: - ABL1 AGO2 ATM ATRX BARD1 BCCIP BCR BLM BRCA1 BRCA2 C1orf112 CASP3 CASP7 CCND1 CDH13 CHD3 CHEK1 CSNK2A1 CSNK2B CST6 CTCF DDB2 DMC1 DNAJA3 DYRK1A ENAH EP400 ERCC2 ERCC5 EVL FANCD2 FANCI FBH1 FIGNL1 HID1 HNRNPC HSP90AA1 IL24 IRS1 ITIH5 MAPK8IP3 MDC1 MMS22L MND1 MSH4 NBN NCL NELFB NXF1 PALB2 PARPBP PCSK1N PDS5B PFN1 PLK1 POLA1 RAD18 RAD51AP1 RAD51AP2 RAD51B RAD51C RAD52 RAD54B RAD54L RECQL5 RELA RFWD3 RPA1 RPA2 RPA3 SEM1 SFR1 SIRT2 ST14 SUMO1 SUMO2 SWSAP1 TFF1 TP53 TP53BP1 UBE2I UCHL3 UGDH UHRF2 UMPS USP10 VASP VIM WDR48 WRN XPO1 XRCC2 XRCC3 ZDHHC17	10 interacting genes: ADIPOQ AURKA CASP8 CCND1 CHEK2 HMMR MAPK6 MTNR1B PTPN1 RAD51
Entrez ID		5888	1012
HPRD ID		01557	03219
Ensembl ID		ENSG00000051180	ENSG00000140945
Uniprot IDs		Q06609	B7Z3H7 B7Z9B1 P55290
PDB IDs		1B22 1N0W 5H1B 5H1C 5JZC 5NP7 5NWL 7C9A	2V37
Enriched GO Terms of Interacting Partners?
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