RAB27B and SYTL4

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)
HPRD (in vivo, in vitro)

		RAB27B	SYTL4
Description		RAB27B, member RAS oncogene family	synaptotagmin like 4
Image
GO Annotations	Cellular Component	Late Endosome Golgi Stack Plasma Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Anchored Component Of Synaptic Vesicle Membrane Axon Cytoplasm	Endosome Plasma Membrane Extrinsic Component Of Membrane Transport Vesicle Membrane Platelet Alpha Granule Membrane Exocytic Vesicle
	Molecular Function	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding	Protein Binding Phospholipid Binding Small GTPase Binding Neurexin Family Protein Binding Metal Ion Binding
	Biological Process	Melanosome Transport Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport	Plasma Membrane Repair Intracellular Protein Transport Exocytosis Lysosome Localization Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion Positive Regulation Of Protein Secretion Multivesicular Body Sorting Pathway Regulation Of Plasma Membrane Repair
Pathways		Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Platelet degranulation
Drugs			Insulin pork
Diseases
GWAS		Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 28892062) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Depression ( 29700475) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Lean body mass ( 28552196) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494)
Interacting Genes		19 interacting genes: CNPY2 DHPS EFHD1 GORASP2 MEX3C MLPH MYRIP NR2E1 RPH3A RPH3AL SEC11A STARD6 SYTL1 SYTL2 SYTL4 SYTL5 TUFT1 UNC13D WDR7	27 interacting genes: CCDC85B CEP70 DVL3 FCHO1 FXR2 HMG20A INS KIFC3 LMO1 LZTS1 OSBPL3 PRKAR1B RAB27A RAB27B RAB3A RAB3D RAB8A ROPN1 SPANXN2 STX1A STXBP1 TBC1D1 TRIM37 TRIM41 ZBTB7B ZBTB9 ZRANB1
Entrez ID		5874	94121
HPRD ID		04846	06735
Ensembl ID		ENSG00000041353	ENSG00000102362
Uniprot IDs		O00194	A0A024RCF8 A8K973 B2R7R4 Q71SF7 Q96C24
PDB IDs		2F7S	2CSZ 3FDW 5X6T
Enriched GO Terms of Interacting Partners?
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