RHOU and PAK4

Number of citations of the paper that reports this interaction (PubMedID 26598620)
28

Data Source:
BioGRID (pull down)

		RHOU	PAK4
Description		ras homolog family member U	p21 (RAC1) activated kinase 4
Image
GO Annotations	Cellular Component	Golgi Membrane Podosome Cytosol Plasma Membrane Focal Adhesion Cell Projection	Cytoplasm Golgi Apparatus Cytosol Adherens Junction Focal Adhesion
	Molecular Function	GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Involved In Cell-cell Adhesion Protein Serine Kinase Activity
	Biological Process	Endocytosis Cytoskeleton Organization Regulation Of Cell Shape Cell Migration Cell Projection Assembly Cdc42 Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Targeting To Mitochondrion	Regulation Of Cell Growth Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Cell Cycle Signal Transduction Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Cell-cell Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle	Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Aging ( 22773346) Basal cell carcinoma ( 33549134 24403052 25855136 27539887 18849993) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)
Interacting Genes		128 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 ARNTL AS3MT ATP5MG ATP6AP1 BDNF BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A ESYT1 FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 MARCKS ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIV2L SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84	25 interacting genes: APP CDC42 DGCR6L DLST FBXO25 FGFR2 G6PD GATAD2A GRB2 H1-1 INKA1 ITGAV ITGB5 LIMK1 POT1 PPARG RAN RHOU SH3RF2 SRPK1 SRPK2 TERF1 YWHAG YWHAQ YWHAZ
Entrez ID		58480	10298
HPRD ID		06965	05675
Ensembl ID		ENSG00000116574	ENSG00000130669
Uniprot IDs		A0A024R3Q7 Q7L0Q8	A0A024R0J1 A0A024R0L8 O96013
PDB IDs		2Q3H	2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4JDH 4JDI 4JDJ 4JDK 4L67 4NJD 4O0V 4O0X 4O0Y 4XBR 4XBU 5BMS 5I0B 5UPK 5UPL 5VED 5VEE 5VEF 5XVA 5XVF 5XVG 5ZJW 6WLX 6WLY
Enriched GO Terms of Interacting Partners?
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