PAK4 and INKA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PAK4	INKA1
Description		p21 (RAC1) activated kinase 4	inka box actin regulator 1
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Adherens Junction Focal Adhesion	Nucleus Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Involved In Cell-cell Adhesion Protein Serine Kinase Activity	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Cell Cycle Signal Transduction Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Cell-cell Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process	Negative Regulation Of Catalytic Activity
Pathways		Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS
Interacting Genes		25 interacting genes: APP CDC42 DGCR6L DLST FBXO25 FGFR2 G6PD GATAD2A GRB2 H1-1 INKA1 ITGAV ITGB5 LIMK1 POT1 PPARG RAN RHOU SH3RF2 SRPK1 SRPK2 TERF1 YWHAG YWHAQ YWHAZ	10 interacting genes: APP C1orf109 DDX6 GPANK1 KIF9 PAK4 PAK5 TRIM55 TRIM63 ZNF417
Entrez ID		10298	389119
HPRD ID		05675	14210
Ensembl ID		ENSG00000130669	ENSG00000185614
Uniprot IDs		A0A024R0J1 A0A024R0L8 O96013	Q96EL1
PDB IDs		2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4JDH 4JDI 4JDJ 4JDK 4L67 4NJD 4O0V 4O0X 4O0Y 4XBR 4XBU 5BMS 5I0B 5UPK 5UPL 5VED 5VEE 5VEF 5XVA 5XVF 5XVG 5ZJW 6WLX 6WLY	4XBR 4XBU
Enriched GO Terms of Interacting Partners?
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