PYCR1 and SIRT3

Number of citations of the paper that reports this interaction (PubMedID 31108370)
9

Data Source:
BioGRID (pull down)

		PYCR1	SIRT3
Description		pyrroline-5-carboxylate reductase 1	sirtuin 3
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Protein-containing Complex
	Molecular Function	Pyrroline-5-carboxylate Reductase Activity Protein Binding Identical Protein Binding	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity Enzyme Binding NAD-dependent Protein Deacetylase Activity Sequence-specific DNA Binding NAD+ Binding
	Biological Process	Proline Biosynthetic Process Cellular Response To Oxidative Stress Regulation Of Mitochondrial Membrane Potential L-proline Biosynthetic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death	Protein ADP-ribosylation Protein Deacetylation Aging Aerobic Respiration Histone Deacetylation Positive Regulation Of Insulin Secretion Peptidyl-lysine Deacetylation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Superoxide Dismutase Activity Positive Regulation Of Catalase Activity Positive Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Glutamate and glutamine metabolism	Transcriptional activation of mitochondrial biogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation
Drugs		NADH Proline	Adenosine-5-Diphosphoribose
Diseases
GWAS			Coronary artery disease ( 33020668) Glycated hemoglobin levels ( 34059833) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Platelet count ( 24026423) Uterine fibroids ( 21460842 30194396)
Interacting Genes		7 interacting genes: BNIPL CDK2AP2 FXR1 HNRNPD NUDT21 SIRT3 TNPO2	8 interacting genes: ALDH2 DNM1L H3C1 MDM2 PDP1 PEX5 PYCR1 XRCC6
Entrez ID		5831	23410
HPRD ID		01528	06836
Ensembl ID		ENSG00000183010	ENSG00000142082
Uniprot IDs		A0A024R8U9 E2QRB3 J3QL32 P32322 Q8TBX0	Q9NTG7
PDB IDs		2GER 2GR9 2GRA 2IZZ 5UAT 5UAU 5UAV 5UAW 5UAX 6XOZ 6XP0 6XP1 6XP2 6XP3	3GLR 3GLS 3GLT 3GLU 4BN4 4BN5 4BV3 4BVB 4BVE 4BVF 4BVG 4BVH 4C78 4C7B 4FVT 4FZ3 4HD8 4JSR 4JT8 4JT9 4O8Z 5BWN 5BWO 5D7N 5H4D 5Y4H 5YTK 5Z93 5Z94 5ZGC 6ISO
Enriched GO Terms of Interacting Partners?
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