PVT1 and ERG

Number of citations of the paper that reports this interaction (PubMedID 31699956)
17

Data Source:
BioGRID (unspecified method)

		PVT1	ERG
Description		Pvt1 oncogene	ETS transcription factor ERG
Image		No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus Cytoplasm Ribonucleoprotein Complex
	Molecular Function		RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process		Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Multicellular Organism Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Allergic sensitization ( 30013184 23817571) Amyotrophic lateral sclerosis (sporadic) ( 24529757) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Basophil count ( 32888494) Bell's palsy ( 33602968) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 32581322) Diffuse large B cell lymphoma ( 25261932) End-stage renal disease ( 17395743) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Follicular lymphoma ( 25279986) Graft survival time in renal transplantation (donor effect) x APOL1 genotype interaction ( 32080893) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hodgkin's lymphoma ( 21037568) Immunoglobulin A ( 20694011) Lung cancer ( 28604730) Lymphocyte counts ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (thyroid preparations) ( 31015401) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Multiple sclerosis ( 31604244 21833088) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Orofacial clefts ( 19270707) Pancreatic cancer ( 25086665) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Psychosis (atypical) ( 24132900) Renal cell carcinoma ( 24220699) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Rheumatoid arthritis ( 30423114 24390342) Seasonality ( 25562672) Selective IgA deficiency ( 27723758) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30297969) Urinary bladder cancer ( 24861552) Urinary calcium excretion ( 31993563) Waist-hip ratio ( 28552196) White blood cell count ( 32888494 27863252)	Abdominal aortic aneurysm ( 27899403) Amyotrophic lateral sclerosis (sporadic) ( 24529757) B-cell acute lymphoblastic leukaemia ( 31767839) B-cell acute lymphoblastic leukaemia (high-hyperdiploidy) ( 31767839) Diastolic blood pressure ( 27841878 30578418) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) General cognitive ability ( 25383866) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota relative abundance (Blautia) ( 33208821) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (iron levels) ( 28334935) Keratinocyte cancer (MTAG) ( 31174203) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (HVA) ( 23319000) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244 27386562) Neonatal lupus ( 20662065) Neutrophil count ( 32888494) Non-response to antidepressants and depression ( 27622933) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)
Interacting Genes		5 interacting genes: ERG KRT9 POTEKP RBM25 RPS16	81 interacting genes: ACTB ADAR APP ATP5PD CDC5L CLTC COL6A2 CRYAA CSTB DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 FBL FLI1 HERC2 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 HUWE1 ILF2 ILF3 ITGB2 JUN LANCL1 MATR3 NCL NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 PDE9A POLR2A PRKDC PRMT2 PRPF40A PRPF8 PUF60 PVT1 RCC2 RING1 RNF2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SNRNP200 SPI1 SPOP STUB1 SYN1 TOP1 TOP2B TRIM25 TRIM33 TRIP12 UBR4 UBR5 UHRF1 USP9X XRN2
Entrez ID		5820	2078
HPRD ID			01298
Ensembl ID		ENSG00000249859	ENSG00000157554
Uniprot IDs			A0A0C4DG41 B4DN83 B4DVX5 B5MDW0 P11308
PDB IDs			1SXE 4IRG 4IRH 4IRI 5YBC 5YBD 6VGE 6VGG
Enriched GO Terms of Interacting Partners?
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