ERG and UBR4

Number of citations of the paper that reports this interaction (PubMedID 27626314)
13

Data Source:
BioGRID (pull down)

		ERG	UBR4
Description		ETS transcription factor ERG	ubiquitin protein ligase E3 component n-recognin 4
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Ribonucleoprotein Complex	Nucleoplasm Centrosome Cytosol Plasma Membrane Membrane Integral Component Of Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Ubiquitin-protein Transferase Activity Protein Binding Calmodulin Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Multicellular Organism Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination
Pathways			Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Verpasep caltespen PCL-016
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) Amyotrophic lateral sclerosis (sporadic) ( 24529757) B-cell acute lymphoblastic leukaemia ( 31767839) B-cell acute lymphoblastic leukaemia (high-hyperdiploidy) ( 31767839) Diastolic blood pressure ( 27841878 30578418) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) General cognitive ability ( 25383866) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota relative abundance (Blautia) ( 33208821) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (iron levels) ( 28334935) Keratinocyte cancer (MTAG) ( 31174203) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (HVA) ( 23319000) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244 27386562) Neonatal lupus ( 20662065) Neutrophil count ( 32888494) Non-response to antidepressants and depression ( 27622933) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Composite immunoglobulin trait (IgA/IgG) ( 28628107)
Interacting Genes		81 interacting genes: ACTB ADAR APP ATP5PD CDC5L CLTC COL6A2 CRYAA CSTB DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 FBL FLI1 HERC2 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 HUWE1 ILF2 ILF3 ITGB2 JUN LANCL1 MATR3 NCL NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 PDE9A POLR2A PRKDC PRMT2 PRPF40A PRPF8 PUF60 PVT1 RCC2 RING1 RNF2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SNRNP200 SPI1 SPOP STUB1 SYN1 TOP1 TOP2B TRIM25 TRIM33 TRIP12 UBR4 UBR5 UHRF1 USP9X XRN2	13 interacting genes: ADRA1A AGTR1 CALM1 ERG MTNR1A MTNR1B PRPF40A SRGN SRPK2 SUMO2 UBC UBE2D2 UBE2L3
Entrez ID		2078	23352
HPRD ID		01298	10184
Ensembl ID		ENSG00000157554	ENSG00000127481
Uniprot IDs		A0A0C4DG41 B4DN83 B4DVX5 B5MDW0 P11308	Q5T4S7
PDB IDs		1SXE 4IRG 4IRH 4IRI 5YBC 5YBD 6VGE 6VGG
Enriched GO Terms of Interacting Partners?
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