CXCL16 and CERS4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CXCL16	CERS4
Description		C-X-C motif chemokine ligand 16	ceramide synthase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Chemokine Activity	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Receptor-mediated Endocytosis Chemotaxis Signal Transduction T Cell Chemotaxis Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Response To Cytokine Response To Interferon-gamma Response To Tumor Necrosis Factor	Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058)	Macular telangiectasia type 2 ( 33654266) Mean reticulocyte volume ( 32888494) Metabolite levels ( 31628463) Red cell distribution width ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingolipid levels ( 26068415) Sphingomyelin levels ( 31551469) Thyroid stimulating hormone levels ( 30367059 32769997) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)
Interacting Genes		64 interacting genes: ADAMTSL4 APP AQP2 AQP6 AQP9 ARL13B ATP6V0E1 BIK CARD10 CCDC70 CD53 CERS4 CLDN7 CREB3L1 CXCR6 CYSRT1 FAM209A FFAR2 FKBP7 FNDC9 GJA8 GORAB GPR42 HHATL HOXA1 KASH5 KIR2DL3 KRT31 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP5-9 LHFPL5 LMNA MDFI MFF MTUS2 MUC1 NBPF19 NEMP1 NOTCH2NLA PEX12 SAR1A SLC16A2 SLC18A1 SLC39A1 SPN SSMEM1 STX1A TAB1 TGM1 TLCD4 TMEM139 TMEM14B TMEM237 TMEM239 TMEM35A TMX2 TSPAN12	47 interacting genes: - C1QL4 CCL4L2 CLEC1A COL4A5 CTXN3 CXCL16 CYB5R3 EMD FATE1 FCER1G FXYD6 FXYD6-FXYD2 GPR151 IER3IP1 IGFBP5 ITGAM JAGN1 LHFPL5 MS4A1 NAT8 NEU1 PLP2 PNLIPRP1 PTPN9 SCAMP5 SCD SERF1A SERF1B SERP2 SLC13A4 SLC29A2 SLC35A1 SLC35F6 SLC7A1 SMIM11 STX7 STX8 TEX264 TMEM119 TMEM176A TMEM254 TMEM72 TOMM6 TSPO2 UPK1B VAMP2
Entrez ID		58191	79603
HPRD ID		16103	13962
Ensembl ID		ENSG00000161921	ENSG00000090661
Uniprot IDs		Q9H2A7	Q53HF9 Q9HA82
PDB IDs
Enriched GO Terms of Interacting Partners?
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