WFDC1 and XRCC2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		WFDC1	XRCC2
Description		WAP four-disulfide core domain 1	X-ray repair cross complementing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Nucleoplasm Replication Fork Cytoplasm Centrosome Rad51B-Rad51C-Rad51D-XRCC2 Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Molecular_function Serine-type Endopeptidase Inhibitor Activity	Four-way Junction DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA
	Biological Process	Regulation Of Cell Growth Response To Xenobiotic Stimulus Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell Growth Response To Estradiol Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Negative Regulation Of Wound Healing	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis DNA Repair Centrosome Cycle Response To X-ray Response To Gamma Radiation Multicellular Organism Growth Strand Invasion Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neurogenesis Meiotic Cell Cycle Regulation Of Fibroblast Apoptotic Process
Pathways			HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Systolic blood pressure (alcohol consumption interaction) ( 24376456) Systolic blood pressure (baseline) ( 33603002) Visceral adipose tissue adjusted for BMI ( 22589738)	Diabetic kidney disease ( 26305897) Mean platelet volume ( 32888494 27863252) Palmitic acid (16:0) levels ( 23362303)
Interacting Genes		6 interacting genes: ETF1 EZR FOSL1 RAB40B XRCC2 ZNF677	5 interacting genes: MEOX2 NKIRAS1 RAD51 RAD51D WFDC1
Entrez ID		58189	7516
HPRD ID		05614	02656
Ensembl ID		ENSG00000103175	ENSG00000196584
Uniprot IDs		Q9HC57	A0A384MEK2 O43543
PDB IDs
Enriched GO Terms of Interacting Partners?
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