PTPRS and SLITRK1

Number of citations of the paper that reports this interaction (PubMedID 25394468)
48

Data Source:
BioGRID (pull down)

		PTPRS	SLITRK1
Description		protein tyrosine phosphatase receptor type S	SLIT and NTRK like family member 1
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Synaptic Vesicle Membrane Axon Growth Cone Perikaryon Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane	Extracellular Region Plasma Membrane Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Heparin Binding Chondroitin Sulfate Binding Heparan Sulfate Proteoglycan Binding	Protein Binding
	Biological Process	Protein Dephosphorylation Negative Regulation Of Neuron Projection Development Spinal Cord Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Corpus Callosum Development Negative Regulation Of Axon Extension Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Modulation Of Chemical Synaptic Transmission Negative Regulation Of Dendritic Spine Development Establishment Of Endothelial Intestinal Barrier Regulation Of Postsynaptic Density Assembly Synaptic Membrane Adhesion	Axonogenesis Synapse Assembly Adult Behavior Multicellular Organism Growth Homeostatic Process Positive Regulation Of Axonogenesis Positive Regulation Of Synapse Assembly Synaptic Membrane Adhesion Regulation Of Presynapse Assembly
Pathways		ECM proteoglycans Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules Signaling by NTRK3 (TRKC)	Receptor-type tyrosine-protein phosphatases
Drugs		Alendronic acid Etidronic acid
Diseases
GWAS		Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes ( 30297969) Waist-hip ratio ( 28552196)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Bipolar disorder (mania) ( 23326512) Carotid intima media thickness x smoking interaction ( 32117412) Cerebral amyloid deposition (PET imaging) ( 30361487) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Hepcidin/transferrin saturation ratio ( 27846281) Heschl's gyrus morphology ( 25130324) Metabolite levels ( 23823483) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Squamous cell lung carcinoma ( 28604730) Temperament (bipolar disorder) ( 22365631)
Interacting Genes		27 interacting genes: CEP126 CHD3 EEF1G EGFR FEZ1 GPC2 GPC3 GPC6 KAT5 MOB4 PFN2 PPFIA1 PPFIA2 PPFIA3 PTN PTPRA PTPRD PTPRE PTPRM PTPRN RAB35 SETDB1 SLITRK1 TUBB2A UBR1 UNC119 UTP14A	3 interacting genes: PTPRD PTPRS UBQLN2
Entrez ID		5802	114798
HPRD ID		03344	18063
Ensembl ID		ENSG00000105426	ENSG00000178235
Uniprot IDs		Q13332 Q59FX6 Q8NHS7	Q96PX8
PDB IDs		2FH7 2YD2 2YD3 2YD9 4BPC 4PBX	4RCA 4RCW
Enriched GO Terms of Interacting Partners?
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