SLITRK1 and PTPRS

Number of citations of the paper that reports this interaction (PubMedID 25394468)
48

Data Source:
BioGRID (pull down)

		SLITRK1	PTPRS
Description		SLIT and NTRK like family member 1	protein tyrosine phosphatase receptor type S
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Density Membrane	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Synaptic Vesicle Membrane Axon Growth Cone Perikaryon Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Heparin Binding Chondroitin Sulfate Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Axonogenesis Synapse Assembly Adult Behavior Multicellular Organism Growth Homeostatic Process Positive Regulation Of Axonogenesis Positive Regulation Of Synapse Assembly Synaptic Membrane Adhesion Regulation Of Presynapse Assembly	Protein Dephosphorylation Negative Regulation Of Neuron Projection Development Spinal Cord Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Corpus Callosum Development Negative Regulation Of Axon Extension Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Modulation Of Chemical Synaptic Transmission Negative Regulation Of Dendritic Spine Development Establishment Of Endothelial Intestinal Barrier Regulation Of Postsynaptic Density Assembly Synaptic Membrane Adhesion
Pathways		Receptor-type tyrosine-protein phosphatases	ECM proteoglycans Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules Signaling by NTRK3 (TRKC)
Drugs			Alendronic acid Etidronic acid
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Bipolar disorder (mania) ( 23326512) Carotid intima media thickness x smoking interaction ( 32117412) Cerebral amyloid deposition (PET imaging) ( 30361487) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Hepcidin/transferrin saturation ratio ( 27846281) Heschl's gyrus morphology ( 25130324) Metabolite levels ( 23823483) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Squamous cell lung carcinoma ( 28604730) Temperament (bipolar disorder) ( 22365631)	Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes ( 30297969) Waist-hip ratio ( 28552196)
Interacting Genes		3 interacting genes: PTPRD PTPRS UBQLN2	27 interacting genes: CEP126 CHD3 EEF1G EGFR FEZ1 GPC2 GPC3 GPC6 KAT5 MOB4 PFN2 PPFIA1 PPFIA2 PPFIA3 PTN PTPRA PTPRD PTPRE PTPRM PTPRN RAB35 SETDB1 SLITRK1 TUBB2A UBR1 UNC119 UTP14A
Entrez ID		114798	5802
HPRD ID		18063	03344
Ensembl ID		ENSG00000178235	ENSG00000105426
Uniprot IDs		Q96PX8	Q13332 Q59FX6 Q8NHS7
PDB IDs		4RCA 4RCW	2FH7 2YD2 2YD3 2YD9 4BPC 4PBX
Enriched GO Terms of Interacting Partners?
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