PTPRN and SPTBN4

Number of citations of the paper that reports this interaction (PubMedID 11086001)
112

Data Source:
HPRD (in vivo, two hybrid)

		PTPRN	SPTBN4
Description		protein tyrosine phosphatase receptor type N	spectrin beta, non-erythrocytic 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle Integral Component Of Membrane Secretory Granule Transport Vesicle Membrane Neuronal Cell Body Perikaryon Axon Terminus Synapse	Cytoplasm Cytosol Actin Filament Plasma Membrane Adherens Junction Spectrin Intercalated Disc Membrane Nuclear Matrix PML Body Cell Junction Cortical Actin Cytoskeleton Node Of Ranvier Paranode Region Of Axon Cell Projection Neuronal Cell Body Axon Initial Segment Axon Hillock Extracellular Exosome Cell Body Fiber
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Transcription Factor Binding Spectrin Binding Ubiquitin-like Protein Ligase Binding GTPase Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Phosphatase Binding Ankyrin Binding Spectrin Binding Actin Filament Binding Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Response To Reactive Oxygen Species Luteinization Cytokine-mediated Signaling Pathway Insulin Secretion Response To Insulin Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Estrogen Positive Regulation Of Transcription By RNA Polymerase II Response To CAMP Positive Regulation Of Type B Pancreatic Cell Proliferation Dense Core Granule Maturation	Regulation Of Sodium Ion Transport Cytoskeleton Organization Axonogenesis Sensory Perception Of Sound Adult Walking Behavior Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Actin Cytoskeleton Organization Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Actin Filament Capping Cardiac Conduction Protein Localization To Plasma Membrane
Pathways			NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Mean reticulocyte volume ( 32888494)	Antibody level in response to infection ( 25758998) Carotid intima media thickness (mean) ( 31801372) Hemoglobin levels ( 32327693) Pulse pressure ( 30578418)
Interacting Genes		19 interacting genes: CAPN2 CCDC134 CLN8 GJA8 GPR152 MADD MAL NOS1 PLP1 PPIA PTPRS PTPRT SNTB2 SNX19 SPTBN4 TIMMDC1 TMEM80 TRDN UBQLN4	16 interacting genes: ANK3 ARC CDC37 CDKL5 CELSR3 CENPU CLK1 DISC1 GADD45A GSK3B NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6 SPTAN1
Entrez ID		5798	57731
HPRD ID		03466	09372
Ensembl ID		ENSG00000054356	ENSG00000160460
Uniprot IDs		Q16849 Q96IA0	Q9H254
PDB IDs		2I1Y 2QT7 3N01 3N4W 3NG8 3NP5
Enriched GO Terms of Interacting Partners?
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