PTPRJ and IL2RG

Number of citations of the paper that reports this interaction (PubMedID 12370829)
26

Data Source:
HPRD (in vivo, in vitro)

		PTPRJ	IL2RG
Description		protein tyrosine phosphatase receptor type J	interleukin 2 receptor subunit gamma
Image
GO Annotations	Cellular Component	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Ruffle Membrane Specific Granule Membrane Extracellular Exosome	Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Activity Protein Kinase Binding Gamma-catenin Binding Cadherin Binding Mitogen-activated Protein Kinase Binding Delta-catenin Binding	Cytokine Receptor Activity Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Cytokine Binding Interleukin-2 Binding Interleukin-15 Receptor Activity
	Biological Process	Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Cell Adhesion B Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Peptidyl-tyrosine Dephosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Contact Inhibition Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis	Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Positive Regulation Of Phagocytosis
Pathways		Phosphorylation of CD3 and TCR zeta chains Neutrophil degranulation Negative regulation of MET activity Negative regulation of FLT3	Interleukin-7 signaling Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling STAT3 nuclear events downstream of ALK signaling
Drugs			Denileukin diftitox Aldesleukin Resatorvid
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Alanine aminotransferase levels ( 33547301) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Caffeine consumption from coffee or tea ( 33287642) D-dimer levels ( 21502573) Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 23563607) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypertension ( 31879980) Intraocular pressure ( 29617998 25173106 31798171 29785010 31959993 30054594 29235454) Kawasaki disease ( 33692975) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Offspring birth weight ( 31043758) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Serum metabolite concentrations in chronic kidney disease ( 33838163) Sleep duration (short sleep) ( 30846698)
Interacting Genes		36 interacting genes: ANP32B BAAT BAP1 CASC3 CTNNB1 CTNND1 CYP17A1 EGFR EPSTI1 FANCC FBP1 HEMGN HOXC6 HRAS IL2RG JUP KLK7 KLK9 LAT LYPD3 MAP2K1 MET NANS NOP2 PDGFRB PLCG1 PPP2CB PPP3R2 PRDM14 RASA1 SDCBP SFRP4 TMEFF1 TRMO TSTD2 ZNF510	27 interacting genes: AXL CAPNS1 ERRFI1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 KRTAP10-8 KRTAP5-7 NOTCH2NLA PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2
Entrez ID		5795	3561
HPRD ID		02955	02391
Ensembl ID		ENSG00000149177	ENSG00000147168
Uniprot IDs		Q12913 Q9NPR5	P31785
PDB IDs		2CFV 2DLE 2NZ6	1ILL 1ILM 1ILN 1ITE 2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7 5M5E 6OEL
Enriched GO Terms of Interacting Partners?
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