PTPN6 and LILRB2

Number of citations of the paper that reports this interaction (PubMedID 9531263)
105

Data Source:
HPRD (in vitro)

		PTPN6	LILRB2
Description		protein tyrosine phosphatase non-receptor type 6	leukocyte immunoglobulin like receptor B2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cell-cell Junction Membrane Protein-containing Complex Specific Granule Lumen Alpha-beta T Cell Receptor Complex Extracellular Exosome Tertiary Granule Lumen	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding Protein Kinase Binding SH2 Domain Binding Cell Adhesion Molecule Binding Phosphorylation-dependent Protein Binding	Amyloid-beta Binding Protein Binding Protein Phosphatase 1 Binding MHC Class Ib Protein Complex Binding MHC Class Ib Protein Binding Inhibitory MHC Class I Receptor Activity MHC Class I Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Cell Adhesion Molecule Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Protein Dephosphorylation G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Formation T Cell Costimulation Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Abortive Mitotic Cell Cycle Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Megakaryocyte Development Negative Regulation Of T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Regulation Of B Cell Differentiation Negative Regulation Of Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Epididymis Development Regulation Of G1/S Transition Of Mitotic Cell Cycle	Adaptive Immune Response Negative Regulation Of Antigen Processing And Presentation Positive Regulation Of Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Learning Or Memory Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-6 Production Heterotypic Cell-cell Adhesion Positive Regulation Of Protein Dephosphorylation Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Calcium Ion Transport Cellular Response To Lipopolysaccharide Interleukin-10-mediated Signaling Pathway Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Depression Negative Regulation Of Postsynaptic Density Organization Negative Regulation Of T Cell Costimulation Regulation Of Dendritic Cell Differentiation
Pathways		GPVI-mediated activation cascade Regulation of KIT signaling Signaling by ALK PECAM1 interactions Costimulation by the CD28 family PD-1 signaling Signal regulatory protein family interactions Platelet sensitization by LDL Interleukin-3, Interleukin-5 and GM-CSF signaling CD22 mediated BCR regulation Neutrophil degranulation Interferon gamma signaling Regulation of IFNG signaling Interleukin-37 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA signaling Growth hormone receptor signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Tiludronic acid
Diseases
GWAS		Mean corpuscular hemoglobin concentration ( 29403010) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576 29875488) HDL cholesterol ( 20686565) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lactate dehydrogenase levels ( 29403010) Nonsyndromic cleft lip ( 31609978)
Interacting Genes		115 interacting genes: AATK ABL1 ACTN1 ACTN4 BCR BLNK BTLA CAV1 CBL CCDC88A CD22 CD247 CD300LF CD33 CD5 CD72 CD79A CD79B CDK1 CEACAM1 CLEC4A CSF2RB CTNNB1 CTNND1 CUZD1 CXCR4 DOK1 EGFR EPOR ERBB2 ERBB3 ERBB4 ESR1 FAS FCGR2B FCRL3 FGFR4 FHL3 FLT3 GAB2 GHR GRB2 HOXA10 IFNAR1 IGF1R IL2RB IL4R IL6ST INSR IRS2 IRS4 JAK1 JAK2 JAK3 KDR KHDRBS1 KIR2DL3 KIR2DL5A KIT KLRA1P KLRB1 KLRC1 LAIR1 LAT LCK LCP2 LIFR LILRB2 LILRB4 LMTK2 LYN MPIG6B MS4A2 MYH9 NOS1 OLIG1 PAG1 PDGFRB PECAM1 PIK3R1 PILRA PILRB PLCG2 PRKCA PRKCD PTK2B PTK7 PTPN11 PTPRC ROR1 ROR2 ROS1 SHC1 SIGLEC10 SIGLEC11 SIGLEC12 SIRPA SLAMF6 SOS1 SPATA2 SRC SSTR2 STAT5B STAT6 SYK TFG TLR10 TMEM62 TNFRSF1A TRAF3 TRAF6 TREML1 TYK2 VAV1 ZAP70	8 interacting genes: FCGR1A FDX1 HLA-A HLA-B HLA-C HLA-F HLA-G PTPN6
Entrez ID		5777	10288
HPRD ID		01475	11994
Ensembl ID		ENSG00000111679	ENSG00000131042
Uniprot IDs		P29350 Q53XS4	A2IXV5
PDB IDs		1FPR 1GWZ 1X6C 2B3O 2RMX 2YU7 3PS5 4GRY 4GRZ 4GS0 4HJP 4HJQ 6SM5
Enriched GO Terms of Interacting Partners?
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