PTPRN2 and RHEB

		PTPRN2	RHEB
Description		protein tyrosine phosphatase receptor type N2	Ras homolog, mTORC1 binding
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GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Synaptic Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Terminal Bouton Receptor Complex Ficolin-1-rich Granule Membrane	Golgi Membrane Spliceosomal Complex Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Postsynaptic Density Membrane Extracellular Exosome
	Molecular Function	Transmembrane Receptor Protein Tyrosine Phosphatase Activity	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding
	Biological Process	Protein Dephosphorylation Lipid Metabolic Process Neurotransmitter Secretion Negative Regulation Of GTPase Activity Peptidyl-tyrosine Dephosphorylation Insulin Secretion Involved In Cellular Response To Glucose Stimulus	Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Cell Cycle Negative Regulation Of Cold-induced Thermogenesis Regulation Of Type B Pancreatic Cell Development
Pathways		Neutrophil degranulation	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs			Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Bipolar disorder and schizophrenia ( 21057379) Breast cancer in childhood cancer survivors ( 29059430) Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy ( 29059430) Calcium levels ( 25972035) Carotid plaque burden ( 28282560) Chronic rhinosinusitis ( 33393196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Diastolic blood pressure ( 27841878) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) Hearing loss in noise exposure ( 33242228) Inflammatory skin disease ( 25574825) Intelligence (MTAG) ( 29326435) Myopia (pathological) ( 23049088) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Obesity-related traits ( 23251661) Plasma anti-thyroid peroxidase levels ( 29678681) Refractive error ( 32231278) Response to amphetamines ( 22952603) Retinal detachment or retinal break ( 31816047) Serum metabolite concentrations in chronic kidney disease ( 29545352) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Triacylglyceride levels ( 31551469)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: CKAP5 RHEB SPTBN4 UBQLN4	35 interacting genes: A2M APOE APPBP2 ARIH2 ATM ATR BNIP3 BNIP3L BRAF CENPE CREB3 ECSIT FKBP8 HTT MAPK15 MTOR NCAM1 NOS3 PDE6D PIGB PLD1 PPP1R3C PSEN1 PSEN2 PTPRN2 RABAC1 RAF1 RNF152 RPS6KB1 RPTOR TRIM55 TRIM63 TSC1 TSC2 USP4
Entrez ID		5799	6009
HPRD ID		03413	03188
Ensembl ID		ENSG00000155093	ENSG00000106615
Uniprot IDs		E7EM83 I6L9F8 Q92932	A0A090N900 Q15382
PDB IDs		2QEP 4HTI 4HTJ	1XTQ 1XTR 1XTS 3SEA 3T5G 5YXH 6BCU 6BSX 6BT0 7BTA 7BTC 7BTD
Enriched GO Terms of Interacting Partners?
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