FANCM and ECT2

Number of citations of the paper that reports this interaction (PubMedID 22990118)
49

Data Source:
BioGRID (two hybrid)

		FANCM	ECT2
Description		FA complementation group M	epithelial cell transforming 2
Image
GO Annotations	Cellular Component	Nucleoplasm Fanconi Anaemia Nuclear Complex FANCM-MHF Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Mitotic Spindle Centralspindlin Complex
	Molecular Function	Four-way Junction DNA Binding Chromatin Binding RNA Helicase Activity Nuclease Activity Protein Binding ATP Binding Four-way Junction Helicase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Replication Fork Processing DNA Duplex Unwinding Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Replication Fork Reversal Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Protein Monoubiquitination	Mitotic Cytokinesis Cell Morphogenesis Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Pathways		Fanconi Anemia Pathway	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Nicotine dependence symptom count ( 25555482) Severe influenza A (H1N1) infection ( 26379185)	Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)
Interacting Genes		11 interacting genes: APP CENPX ECT2 EME2 EPN2 FAAP24 LRRK2 RMI1 RMI2 TRIM27 UBE2I	39 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB USP7 VDAC2
Entrez ID		57697	1894
HPRD ID		13876	11860
Ensembl ID		ENSG00000187790	ENSG00000114346
Uniprot IDs		Q8IYD8	Q9H8V3
PDB IDs		4BXO 4DAY 4DRB 4E45 4M6W	3L46 4N40 6L30
Enriched GO Terms of Interacting Partners?
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