RNF213 and TRIP6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		RNF213	TRIP6
Description		ring finger protein 213	thyroid hormone receptor interactor 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Membrane	Stress Fiber Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion
	Molecular Function	Ubiquitin-protein Transferase Activity ATP Hydrolysis Activity Metal Ion Binding	RNA Binding Interleukin-1 Receptor Binding Protein Binding Kinase Binding Metal Ion Binding Thyroid Hormone Receptor Binding
	Biological Process	Angiogenesis Sprouting Angiogenesis Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Homooligomerization Protein Autoubiquitination Negative Regulation Of Non-canonical Wnt Signaling Pathway	Signal Transduction Positive Regulation Of Cell Migration Chordate Embryonic Development Focal Adhesion Assembly Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		Suppression of apoptosis Signaling by ALK fusions and activated point mutants Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Aspartate aminotransferase levels ( 33547301) Coronary artery disease ( 33020668) Hypertension ( 32709000) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Migraine ( 27182965 27322543) Moyamoya disease ( 21048783 29273593)	Bipolar disorder ( 31043756) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		14 interacting genes: GOLGA2 KRT40 MTDH PLAC9 REL RPTOR SUMO2 TRIM23 TRIM27 TRIP6 UBE2D2 UBE2D3 UBE2L3 UBXN11	165 interacting genes: ABI2 ADAMTSL4 AQP1 ARNT2 ATN1 ATP23 ATP5PO ATXN1 AXIN1 BAG3 BCAR1 BEX2 BYSL C11orf87 CATSPER1 CBLC CCDC120 CCDC187 CCDC24 CCL5 CEP57L1 CNTF CREB5 CRYBA4 CTAG2 DHX37 DMRT3 DTX2 EFHC1 EPDR1 ERBB2 EXOC3-AS1 FAM124B FAM222B FARS2 FAS FASLG FHL3 FOXD4L1 FRS3 GAD1 GATA1 GDPD5 GFI1B GLIS3 GNAI2 GNE GPS2 GSE1 HCK HLA-DPB1 HOXA1 HOXA9 HOXB9 HOXC8 HYKK IL16 ILF3 INCA1 IP6K3 IQCN ITGB4 KCTD9 KIF1A KIR2DL4 KLK15 KPRP KRTAP26-1 LMO2 LNX1 LPAR2 MAPKBP1 MEMO1 METTL17 MIEN1 MIIP MISP MSRB3 MVP NCK2 NEDD9 NEU4 NOL4L-DT NR1D2 NSMF NUP210 ODF1 OIP5 OTUB2 OTX1 PATZ1 PDGFRB PDLIM4 PER1 PIGS PIN1 PLEKHN1 POM121 POM121L4P PPP1R16A PRKAA1 PRKAA2 PTK2 PTPN13 PTPN14 PXN RAD23A RANBP3L RELN RERE RFX3 RHOA RHOQ RNF213 RNF214 SAXO1 SCAND1 SCRIB SETDB1 SHISA6 SIK3 SLC15A3 SLC25A6 SMAD1 SMG9 SNAI1 SON SRC STAC STK16 SVIL SYNGAP1 TAB1 TBC1D22B TCAF1 TEKT4 TENT5C THRB TIE1 TLE5 TLR2 TMSB4X TPM3 TPM4 TRAF3IP2 TRAPPC2L TRIM29 TSGA10IP TSSK3 TTC23 TTLL10 TXN2 TXNDC5 USP2 VASN VCL WT1-AS YPEL3 ZBP1 ZIC1 ZNF541 ZNF580 ZNF581 ZNF688 ZNF785
Entrez ID		57674	7205
HPRD ID		10716	04242
Ensembl ID		ENSG00000173821	ENSG00000087077
Uniprot IDs		A0A0A0MTC1 A0A0A0MTR7 Q63HN8	Q15654
PDB IDs			1X61 2DLO
Enriched GO Terms of Interacting Partners?
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