WDR48 and PHLPP1

Number of citations of the paper that reports this interaction (PubMedID 24145035)
29

Data Source:
BioGRID (affinity chromatography technology, pull down)

		WDR48	PHLPP1
Description		WD repeat domain 48	PH domain and leucine rich repeat protein phosphatase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Lysosome Late Endosome Cytosol Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Ubiquitin Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Cellular Response To DNA Damage Stimulus Spermatogenesis Single Fertilization Protein Deubiquitination Multicellular Organism Growth Skin Development Embryonic Organ Development Skeletal System Morphogenesis Homeostasis Of Number Of Cells Positive Regulation Of Epithelial Cell Proliferation Seminiferous Tubule Development Regulation Of Protein Monoubiquitination Positive Regulation Of Protein Deubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	Regulation Of T Cell Anergy Protein Dephosphorylation Apoptotic Process Signal Transduction Entrainment Of Circadian Clock Regulation Of Apoptotic Process Regulation Of MAPK Cascade Regulation Of JNK Cascade Negative Regulation Of Protein Kinase B Signaling Regulation Of P38MAPK Cascade
Pathways		Recognition of DNA damage by PCNA-containing replication complex Ub-specific processing proteases Fanconi Anemia Pathway Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	Negative regulation of the PI3K/AKT network
Drugs
Diseases
GWAS		Metabolic syndrome ( 31589552) Social communication problems ( 24564958)	Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Hip circumference adjusted for BMI ( 28552196) Plateletcrit ( 32888494)
Interacting Genes		9 interacting genes: FANCI NMRAL1 PAXIP1 PCNA PHLPP1 RAD51 TOPAZ1 UBC USP1	8 interacting genes: BRAP CSNK1A1 GSK3B SERPINB7 SLC9A3R1 SUGT1 WDR48 ZCCHC2
Entrez ID		57599	23239
HPRD ID		11146	15145
Ensembl ID		ENSG00000114742	ENSG00000081913
Uniprot IDs		A0A024R2L1 Q8TAF3	O60346
PDB IDs		5CVL 5CVN 5CVO 5K1A 5K1B 5K1C 5L8E 5L8W 6JLQ
Enriched GO Terms of Interacting Partners?
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