PHLPP1 and WDR48

Number of citations of the paper that reports this interaction (PubMedID 24145035)
29

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PHLPP1	WDR48
Description		PH domain and leucine rich repeat protein phosphatase 1	WD repeat domain 48
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Lysosome Late Endosome Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Ubiquitin Binding
	Biological Process	Regulation Of T Cell Anergy Protein Dephosphorylation Apoptotic Process Signal Transduction Entrainment Of Circadian Clock Regulation Of Apoptotic Process Regulation Of MAPK Cascade Regulation Of JNK Cascade Negative Regulation Of Protein Kinase B Signaling Regulation Of P38MAPK Cascade	Double-strand Break Repair Via Homologous Recombination Cellular Response To DNA Damage Stimulus Spermatogenesis Single Fertilization Protein Deubiquitination Multicellular Organism Growth Skin Development Embryonic Organ Development Skeletal System Morphogenesis Homeostasis Of Number Of Cells Positive Regulation Of Epithelial Cell Proliferation Seminiferous Tubule Development Regulation Of Protein Monoubiquitination Positive Regulation Of Protein Deubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Negative regulation of the PI3K/AKT network	Recognition of DNA damage by PCNA-containing replication complex Ub-specific processing proteases Fanconi Anemia Pathway Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
Drugs
Diseases
GWAS		Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Hip circumference adjusted for BMI ( 28552196) Plateletcrit ( 32888494)	Metabolic syndrome ( 31589552) Social communication problems ( 24564958)
Interacting Genes		8 interacting genes: BRAP CSNK1A1 GSK3B SERPINB7 SLC9A3R1 SUGT1 WDR48 ZCCHC2	9 interacting genes: FANCI NMRAL1 PAXIP1 PCNA PHLPP1 RAD51 TOPAZ1 UBC USP1
Entrez ID		23239	57599
HPRD ID		15145	11146
Ensembl ID		ENSG00000081913	ENSG00000114742
Uniprot IDs		O60346	A0A024R2L1 Q8TAF3
PDB IDs			5CVL 5CVN 5CVO 5K1A 5K1B 5K1C 5L8E 5L8W 6JLQ
Enriched GO Terms of Interacting Partners?
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