PTH2R and PTH

Number of citations of the paper that reports this interaction (PubMedID 9482662)
1

Data Source:
HPRD (in vivo)

		PTH2R	PTH
Description		parathyroid hormone 2 receptor	parathyroid hormone
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space
	Molecular Function	Parathyroid Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding	Hormone Activity Protein Binding Parathyroid Hormone Receptor Binding Type 1 Parathyroid Hormone Receptor Binding Protein N-terminus Binding Receptor Ligand Activity Peptide Hormone Receptor Binding
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Skeletal System Development Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Rho Protein Signal Transduction Cell-cell Signaling Hormone-mediated Apoptotic Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Signal Transduction Response To Lead Ion Regulation Of Gene Expression Negative Regulation Of Gene Expression Magnesium Ion Homeostasis Positive Regulation Of Bone Mineralization Negative Regulation Of Chondrocyte Differentiation Response To Vitamin D Cellular Macromolecule Biosynthetic Process Bone Resorption Response To Ethanol Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II CAMP Metabolic Process Positive Regulation Of Glucose Import Response To Cadmium Ion Homeostasis Of Number Of Cells Within A Tissue Phosphate Ion Homeostasis Positive Regulation Of Inositol Phosphate Biosynthetic Process Response To Parathyroid Hormone Response To Fibroblast Growth Factor Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Osteoclast Proliferation Negative Regulation Of Bone Mineralization Involved In Bone Maturation
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Parathyroid hormone	D-norleucine ABX-PTH
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anthropometric traits ( 30576415) Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334) Metabolite levels ( 23823483) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744)	Bone mineral density ( 19874204) Childhood ear infection ( 27182965) Menarche (age at onset) ( 25231870) Progression free survival in serous epithelial ovarian cancer treated with carboplatin and paclitaxel ( 28935272)
Interacting Genes		6 interacting genes: CALM1 DYNLT1 GRHPR HMG20A PTH PTH2	7 interacting genes: ASPH BAG6 FEZ1 MEP1A OS9 PTH1R PTH2R
Entrez ID		5746	5741
HPRD ID		03276	01345
Ensembl ID		ENSG00000144407	ENSG00000152266
Uniprot IDs		B4DFN8 P49190	P01270
PDB IDs			1BWX 1ET1 1ET2 1FVY 1HPH 1HPY 1HTH 1ZWA 1ZWB 1ZWD 1ZWE 1ZWF 1ZWG 2L1X 3C4M
Enriched GO Terms of Interacting Partners?
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