GNB1 and GNG2

Number of citations of the paper that reports this interaction (PubMedID 8636150)
28

Data Source:
HPRD (two hybrid, in vivo)

		GNB1	GNG2
Description		G protein subunit beta 1	G protein subunit gamma 2
Image
GO Annotations	Cellular Component	Photoreceptor Inner Segment Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Photoreceptor Outer Segment Membrane Cell Body Synapse Extracellular Exosome Photoreceptor Disc Membrane Extracellular Vesicle	Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding Signaling Receptor Complex Adaptor Activity Spectrin Binding Protein-containing Complex Binding Alkylglycerophosphoethanolamine Phosphodiesterase Activity GTPase Binding	Protein Binding G-protein Beta-subunit Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration G Protein-coupled Acetylcholine Receptor Signaling Pathway Ras Protein Signal Transduction Cell Population Proliferation Cardiac Muscle Cell Apoptotic Process Sensory Perception Of Taste Retina Development In Camera-type Eye Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Cellular Response To Catecholamine Stimulus	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Olfactory Signaling Pathway Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Halothane
Diseases
GWAS		Body mass index ( 26426971 25673413) Diastolic blood pressure ( 27841878) Systolic blood pressure ( 27841878)	Body shape index ( 34021172) Chronic obstructive pulmonary disease ( 25584925) Cognitive decline rate in late mild cognitive impairment ( 26252872) Craniofacial microsomia ( 26853712) High density lipoprotein cholesterol levels ( 29403010) Lung cancer (smoking interaction) ( 24658283) Non-melanoma skin cancer ( 23548203) Post bronchodilator FEV1/FVC ratio ( 26634245) Triglyceride levels ( 31170924) Triglyceride levels x loop diuretics use interaction ( 31806883) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		46 interacting genes: ADRA2A ADRB2 AFP ARHGEF18 ATXN10 AVPR2 BTK CACNA1A CACNA1B CACNA1C CDC42 CTNNA3 CYFIP1 DISC1 EPHA7 EXOC5 GNA12 GNAS GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 HDAC5 KCNJ3 MCF2 MRGPRX1 MTNR1A MTNR1B NOL11 NR3C1 PDCL PTH1R RACK1 RASD1 RASD2 SLC35E2A SSU72 TBXA2R VAC14	18 interacting genes: ADCY2 ADRA2A ADRB2 AVPR2 BTK CACNA1H CHRM2 GNAI1 GNB1 GNB2 GNB3 GNB4 GNB5 MRGPRX1 PGGT1B PLEKHG2 SMURF2 TBXA2R
Entrez ID		2782	54331
HPRD ID		00766	16234
Ensembl ID		ENSG00000078369	ENSG00000186469
Uniprot IDs		A0A140VJJ8 B3KVK2 P62873	P59768
PDB IDs		4KFM 4PNK 5HE0 5HE1 5HE2 5HE3 5UKK 5UKL 5UKM 5UZ7 6B3J 6CRK 6D9H 6DDE 6DDF 6E3Y 6EG8 6G79 6GDG 6KPF 6KPG 6LFM 6LFO 6LI3 6LMK 6LML 6M1H 6M1I 6M8S 6N4B 6NI3 6NIY 6OIJ 6OIK 6OMM 6ORV 6OS9 6OSA 6OT0 6P9X 6P9Y 6PB0 6PB1 6PT0 6UUN 6UUS 6UVA 6VCB 6VMS 6VN7 6WHA 6WHC 6WI9 6WPW 6WZG 6X18 6X19 6X1A 6XBJ 6XBK 6XBL 6XBM 6XOX 7C2E 7CFM 7CFN 7CKW 7CKX 7CKY 7CKZ 7CRH 7D76 7D77 7D7M 7JV5 7JVP 7JVQ 7JVR 7K7L 7K7Z 7L0P 7L0Q 7L0R 7L0S 7L1U 7L1V 7LCI	4KFM 5HE0 5HE1 5HE2 5HE3 5UKK 5UKL 5UKM 5UZ7 6B3J 6CRK 6D9H 6DDE 6DDF 6E3Y 6EG8 6G79 6GDG 6K41 6K42 6KPF 6KPG 6LFM 6LFO 6LI3 6LMK 6LML 6M1H 6M1I 6M8S 6N4B 6NI3 6NIY 6OIJ 6OIK 6OMM 6ORV 6OS9 6OSA 6OT0 6P9X 6P9Y 6PB0 6PB1 6PT0 6UUN 6UUS 6UVA 6VCB 6VMS 6VN7 6WHA 6WHC 6WI9 6WPW 6WWZ 6WZG 6X18 6X19 6X1A 6XBJ 6XBK 6XBL 6XBM 6XOX 7C2E 7CFM 7CFN 7CKW 7CKX 7CKY 7CKZ 7CRH 7D76 7D77 7D7M 7JV5 7JVP 7JVQ 7JVR 7K7L 7K7Z 7L1U 7L1V 7LCI
Enriched GO Terms of Interacting Partners?
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