PTGS1 and NUCB1

Number of citations of the paper that reports this interaction (PubMedID 8643612)
19

Data Source:
HPRD (in vitro, two hybrid)

		PTGS1	NUCB1
Description		prostaglandin-endoperoxide synthase 1	nucleobindin 1
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Intracellular Membrane-bounded Organelle Extracellular Exosome	Extracellular Space Nucleus Early Endosome Endoplasmic Reticulum Lumen Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi-associated Vesicle Cis-Golgi Network Trans-Golgi Network Membrane Golgi Cisterna Membrane Extracellular Exosome Extrinsic Component Of Golgi Membrane Lumenal Side Of Golgi Membrane
	Molecular Function	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Protein Binding Heme Binding Metal Ion Binding Dioxygenase Activity	G-protein Alpha-subunit Binding DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding
	Biological Process	Prostaglandin Biosynthetic Process Inflammatory Response Response To Oxidative Stress Regulation Of Blood Pressure Cyclooxygenase Pathway Regulation Of Cell Population Proliferation Cellular Oxidant Detoxification	Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity Response To Cisplatin Regulation Of Protein Targeting
Pathways		COX reactions Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Dihomo-gamma-linolenic acid Icosapent Mesalazine Acetaminophen Indomethacin Minoxidil Nabumetone Ketorolac Tenoxicam Tolmetin Piroxicam Fenoprofen Diclofenac Sulindac Diethylcarbamazine Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicylic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Ibuprofen Lumiracoxib Magnesium salicylate Salsalate Choline magnesium trisalicylate Antrafenine Antipyrine Tiaprofenic acid O-acetyl-L-serine Hyperforin (+)-2-(4-biphenyl)propionic acid Protoporphyrin Ix Containing Co 2-Bromoacetyl Group Flufenamic acid Beta-D-Glucose Resveratrol (3-Chloro-4-Propoxy-Phenyl)-Acetic Acid Acetic Acid Salicyloyl-Amino-Ester P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid Flurbiprofen Methyl Ester Phenacetin Niflumic acid Arachidonic Acid Metamizole Lornoxicam Aceclofenac Nepafenac 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1R)-1-(hydroxymethyl)propyl]acetamide 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1S)-1-(hydroxymethyl)propyl]acetamide Triflusal Cannabidiol Loxoprofen Dexibuprofen Dexketoprofen Droxicam Tolfenamic acid Propacetamol Talniflumate Phenyl salicylate Trolamine salicylate Menthyl salicylate Glycol salicylate Nitroaspirin Bufexamac Bendazac Acemetacin Medical Cannabis Nabiximols	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Glomerular filtration rate in chronic kidney disease ( 26420894) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		3 interacting genes: NCL NUCB1 PTGIS	18 interacting genes: GNAI1 GNAI2 GNAI3 GNAO1 GNAS GNAZ HIVEP1 HOXA1 MYC NDN PLOD2 PTGS1 PTGS2 RBL1 REL SET SIRPA XPO1
Entrez ID		5742	4924
HPRD ID		07518	03205
Ensembl ID		ENSG00000095303	ENSG00000104805
Uniprot IDs		A0A087X296 P23219	A8K7Q1 Q02818
PDB IDs		6Y3C	1SNL
Enriched GO Terms of Interacting Partners?
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