JPH3 and SMO

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		JPH3	SMO
Description		junctophilin 3	smoothened, frizzled class receptor
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Integral Component Of Membrane Junctional Membrane Complex	Golgi Apparatus Plasma Membrane Caveola Cilium Integral Component Of Membrane Dendrite Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane Extracellular Exosome Ciliary Tip 9+0 Non-motile Cilium
	Molecular Function	Molecular_function Protein Binding	G Protein-coupled Receptor Activity Patched Binding Protein Binding
	Biological Process	Learning Memory Exploration Behavior Locomotion Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Neuromuscular Process Controlling Balance Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcium Ion Transport Into Cytosol	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Neural Crest Cell Migration Heart Looping Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Determination Of Left/right Asymmetry In Lateral Mesoderm Type B Pancreatic Cell Development G Protein-coupled Receptor Signaling Pathway Smoothened Signaling Pathway Positive Regulation Of Hh Target Transcription Factor Activity Ventral Midline Determination Central Nervous System Development Midgut Development Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Dentate Gyrus Development Cerebellar Cortex Morphogenesis Thalamus Development Dorsal/ventral Neural Tube Patterning Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Central Nervous System Neuron Differentiation Cerebral Cortex Development Positive Regulation Of Cell Migration Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Astrocyte Activation Skeletal Muscle Fiber Development Smooth Muscle Tissue Development Forebrain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Epithelial Cell Proliferation Protein Stabilization Myoblast Migration Negative Regulation Of Hair Follicle Development Contact Inhibition Atrial Septum Morphogenesis Mammary Gland Epithelial Cell Differentiation Epithelial-mesenchymal Cell Signaling Somite Development Pancreas Morphogenesis Left/right Axis Specification Cellular Response To Cholesterol Commissural Neuron Axon Guidance Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Stem Cell Population Maintenance Regulation Of Heart Morphogenesis
Pathways			Class B/2 (Secretin family receptors) Hedgehog 'off' state BBSome-mediated cargo-targeting to cilium Hedgehog 'on' state Activation of SMO Activation of SMO
Drugs			Fluocinonide Halcinonide Vismodegib Sonidegib Glasdegib
Diseases
GWAS		Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Height ( 28552196) Idiopathic dilated cardiomyopathy ( 29495422) Ischemic stroke ( 29531354) Late-onset Alzheimer's disease ( 27770636) Migraine ( 27182965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Refractive error ( 32231278) Small vessel stroke ( 27997041) Systemic juvenile idiopathic arthritis ( 27927641)	Osteoarthritis (hip) ( 30374069)
Interacting Genes		7 interacting genes: BGN CCR2 KRTAP10-8 PPP1CA SMAD3 SMO TSHR	28 interacting genes: ARV1 C18orf32 C4orf3 EMC10 FKBP8 GABARAPL2 GABBR1 HMGN4 HMOX1 HMOX2 ITGB1BP1 JPH3 LEPROT NDFIP1 NEDD4 NGEF NIPA1 PLPP7 PTCH1 PTCH2 RPN2 S1PR5 SLC41A3 SSPN TIMMDC1 TMCC2 TSPAN7 WLS
Entrez ID		57338	6608
HPRD ID		05589	03294
Ensembl ID		ENSG00000154118	ENSG00000128602
Uniprot IDs		B4DIC1 F8W9A3 Q8WXH2 Q96HD8	Q99835
PDB IDs			4JKV 4N4W 4O9R 4QIM 4QIN 5L7D 5L7I 5V56 5V57 6OT0 6XBJ 6XBK 6XBL 6XBM
Enriched GO Terms of Interacting Partners?
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