SMO and TMCC2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		SMO	TMCC2
Description		smoothened, frizzled class receptor	transmembrane and coiled-coil domain family 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Caveola Cilium Integral Component Of Membrane Dendrite Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane Extracellular Exosome Ciliary Tip 9+0 Non-motile Cilium	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Integral Component Of Membrane
	Molecular Function	G Protein-coupled Receptor Activity Patched Binding Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Neural Crest Cell Migration Heart Looping Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Determination Of Left/right Asymmetry In Lateral Mesoderm Type B Pancreatic Cell Development G Protein-coupled Receptor Signaling Pathway Smoothened Signaling Pathway Positive Regulation Of Hh Target Transcription Factor Activity Ventral Midline Determination Central Nervous System Development Midgut Development Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Dentate Gyrus Development Cerebellar Cortex Morphogenesis Thalamus Development Dorsal/ventral Neural Tube Patterning Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Central Nervous System Neuron Differentiation Cerebral Cortex Development Positive Regulation Of Cell Migration Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Astrocyte Activation Skeletal Muscle Fiber Development Smooth Muscle Tissue Development Forebrain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Epithelial Cell Proliferation Protein Stabilization Myoblast Migration Negative Regulation Of Hair Follicle Development Contact Inhibition Atrial Septum Morphogenesis Mammary Gland Epithelial Cell Differentiation Epithelial-mesenchymal Cell Signaling Somite Development Pancreas Morphogenesis Left/right Axis Specification Cellular Response To Cholesterol Commissural Neuron Axon Guidance Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Stem Cell Population Maintenance Regulation Of Heart Morphogenesis	Amyloid Precursor Protein Metabolic Process
Pathways		Class B/2 (Secretin family receptors) Hedgehog 'off' state BBSome-mediated cargo-targeting to cilium Hedgehog 'on' state Activation of SMO Activation of SMO
Drugs		Fluocinonide Halcinonide Vismodegib Sonidegib Glasdegib
Diseases
GWAS		Osteoarthritis (hip) ( 30374069)	Basophil percentage of white cells ( 32888494) Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 22139419 24026423 19820697 32888494 27863252) Meat-related diet ( 32066663) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 22139419 32888494) Platelet distribution width ( 27863252) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White blood cell count ( 32888494)
Interacting Genes		28 interacting genes: ARV1 C18orf32 C4orf3 EMC10 FKBP8 GABARAPL2 GABBR1 HMGN4 HMOX1 HMOX2 ITGB1BP1 JPH3 LEPROT NDFIP1 NEDD4 NGEF NIPA1 PLPP7 PTCH1 PTCH2 RPN2 S1PR5 SLC41A3 SSPN TIMMDC1 TMCC2 TSPAN7 WLS	31 interacting genes: ADRB2 AKT1 AMOTL2 APP CCDC33 CDR2 CFAP206 DIP2A DPY30 EIF4E2 FAM161A FAM74A4 FAM90A1 FBF1 HGS HNRNPLL HSPD1 IQUB KAT5 PRPF31 PTOV1 RHOXF2 SMO TLE5 UBA1 WT1-AS ZNF250 ZNF417 ZNF581 ZNF587 ZNF688
Entrez ID		6608	9911
HPRD ID		03294	11040
Ensembl ID		ENSG00000128602	ENSG00000133069
Uniprot IDs		Q99835	A0A0C4DFR1 O75069 Q8IW47
PDB IDs		4JKV 4N4W 4O9R 4QIM 4QIN 5L7D 5L7I 5V56 5V57 6OT0 6XBJ 6XBK 6XBL 6XBM
Enriched GO Terms of Interacting Partners?
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