PTGER2 and PTGES

Number of citations of the paper that reports this interaction (PubMedID 8163486)
34

Data Source:
HPRD (in vivo)

		PTGER2	PTGES
Description		prostaglandin E receptor 2	prostaglandin E synthase
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Nuclear Envelope Lumen Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Prostaglandin E Receptor Activity	Glutathione Transferase Activity Glutathione Peroxidase Activity Prostaglandin-D Synthase Activity Protein Binding Glutathione Binding Prostaglandin-E Synthase Activity
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Gastric Mucosal Blood Circulation	Prostaglandin Biosynthetic Process Acute Inflammatory Response Chronic Inflammatory Response Prostaglandin Metabolic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Organic Cyclic Compound Sensory Perception Of Pain Regulation Of Fever Generation Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Response To Retinoic Acid Response To Cytokine Regulation Of Inflammatory Response Response To Calcium Ion Cellular Oxidant Detoxification
Pathways		Prostanoid ligand receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Alprostadil Dinoprostone Misoprostol Gemeprost Limaprost
Diseases
GWAS			Asthma ( 27611488) Pars orbitalis volume ( 31530798) Type 1 diabetes (age at diagnosis) ( 33179336)
Interacting Genes		3 interacting genes: PTGDS PTGES PTGFR	18 interacting genes: BET1 C4orf3 EHHADH GIMAP1 GIMAP5 PLP2 PTGER1 PTGER2 SEC22A SERP2 SMCO4 TMEM19 TMEM222 TMEM65 VAMP3 VAMP4 VAPB YIF1A
Entrez ID		5732	9536
HPRD ID		08905	05528
Ensembl ID		ENSG00000125384	ENSG00000148344
Uniprot IDs		P43116	O14684
PDB IDs			3DWW 4AL0 4AL1 4BPM 4WAB 4YK5 4YL0 4YL1 4YL3 5BQG 5BQH 5BQI 5K0I 5T36 5T37 5TL9 6VL4
Enriched GO Terms of Interacting Partners?
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