PTGER2 and PTGDS

Number of citations of the paper that reports this interaction (PubMedID 8163486)
34

Data Source:
HPRD (in vivo)

		PTGER2	PTGDS
Description		prostaglandin E receptor 2	prostaglandin D2 synthase
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Prostaglandin E Receptor Activity	Prostaglandin-D Synthase Activity Retinoid Binding Fatty Acid Binding Protein Binding Small Molecule Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Gastric Mucosal Blood Circulation	Prostaglandin Biosynthetic Process Cyclooxygenase Pathway Mast Cell Degranulation Regulation Of Circadian Sleep/wake Cycle, Sleep
Pathways		Prostanoid ligand receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Transcriptional regulation of testis differentiation
Drugs		Alprostadil Dinoprostone Misoprostol Gemeprost Limaprost	Vitamin A
Diseases
GWAS			Beta-trace protein levels ( 23328707) Blood protein levels ( 29875488) Corneal structure ( 23291589) Keratoconus ( 33649486)
Interacting Genes		3 interacting genes: PTGDS PTGES PTGFR	22 interacting genes: ADRB2 AKT1 ARRB2 ATXN1 BCAT2 CACNA1A CAPN1 CARD10 CYSRT1 EGFR HK2 HK3 HSP90AA1 KRTAP10-3 KRTAP10-7 KRTAP12-3 MLH1 PTGER1 PTGER2 PTGFR SHBG UBQLN2
Entrez ID		5732	5730
HPRD ID		08905	08904
Ensembl ID		ENSG00000125384	ENSG00000107317
Uniprot IDs		P43116	A0A024R8G3 P41222
PDB IDs			2WWP 3O19 3O22 3O2Y 4IMN 4IMO 4ORR 4ORS 4ORU 4ORW 4ORX 4ORY 4OS0 4OS3 4OS8 5WY9
Enriched GO Terms of Interacting Partners?
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