SPRYD7 and AGXT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPRYD7	AGXT
Description		SPRY domain containing 7	alanine--glyoxylate and serine--pyruvate aminotransferase
Image
GO Annotations	Cellular Component		Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Serine-pyruvate Transaminase Activity Protein Binding Alanine-glyoxylate Transaminase Activity Transaminase Activity Amino Acid Binding Pyridoxal Phosphate Binding Identical Protein Binding Protein Homodimerization Activity Protein Self-association
	Biological Process		Glyoxylate Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-cysteine Catabolic Process L-alanine Catabolic Process Pyruvate Biosynthetic Process Glyoxylate Metabolic Process Response To Glucocorticoid Response To CAMP
Pathways			Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import
Drugs			Pyridoxal phosphate Serine Glycine Alanine Aminooxyacetic acid N(6)-(pyridoxal phosphate)-L-lysine 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID
Diseases
GWAS		Waist-to-hip ratio adjusted for body mass index ( 28430825)	Blood metabolite levels ( 24816252) Height ( 25282103 31562340) Urinary metabolites ( 26352407)
Interacting Genes		14 interacting genes: AGXT AQP1 CAMK2B HEMK1 NTAQ1 OTX1 PDZD3 POGZ TLX3 TRIM55 TRIM63 TRIP13 VAC14 YPEL3	40 interacting genes: ACAT1 ATXN1L BATF3 C11orf1 C19orf54 CHIC2 CYSRT1 EFS FAM168B FHL5 FNTB FOSB GLP1R HOXA1 KRT31 KRT34 KRT37 KRT40 KRTAP1-1 KRTAP12-3 KRTAP3-1 KRTAP6-3 KRTAP8-1 KRTAP9-2 LPXN LYN MDFI MORN5 NBPF19 NOTCH2NLA OIP5 PEX5 PLA2G10 PRDM6 PRICKLE4 RFX6 SNCAIP SPRYD7 TRAPPC14 TTC19
Entrez ID		57213	189
HPRD ID		08486	05048
Ensembl ID		ENSG00000123178	ENSG00000172482
Uniprot IDs		A0A024RDT6 Q5W111	P21549
PDB IDs		7CCB	1H0C 1J04 2YOB 3R9A 4CBR 4CBS 4I8A 4KXK 4KYO 5F9S 5HHY 5LUC 5OFY 5OG0 6RV0 6RV1
Enriched GO Terms of Interacting Partners?
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