TLN1 and ITGB7

Number of citations of the paper that reports this interaction (PubMedID 12606711)
126

Data Source:
HPRD (in vitro)

		TLN1	ITGB7
Description		talin 1	integrin subunit beta 7
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Ruffle Membrane Extracellular Exosome	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alpha4-beta7 Complex Receptor Complex Extracellular Exosome
	Molecular Function	Phosphatidylserine Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding	Virus Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Cell-cell Junction Assembly Cell-substrate Junction Assembly Integrin-mediated Signaling Pathway Cortical Actin Cytoskeleton Organization Integrin Activation Platelet Aggregation Cell-cell Adhesion	Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Migration Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Receptor Clustering Viral Entry Into Host Cell Leukocyte Tethering Or Rolling T Cell Migration
Pathways		Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions
Drugs			R1295 Vedolizumab
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) IgE levels in asthmatics ( 23967269) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494)	Obesity-related traits ( 23251661) Type 1 diabetes ( 34127860)
Interacting Genes		31 interacting genes: ABI1 ACTA1 AZIN2 CCL19 CDK5 DAG1 DOK1 EGFR ERBB2 HSP90AA1 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP PKD1 PTK2 PTK2B PXN SMURF1 SUMO2 TES TUBA1A VCL YWHAQ	17 interacting genes: CDH1 CYP27B1 DAB1 DOK1 EED FLNA FN1 ITGA4 ITGAE MADCAM1 PRKCB PRKCD RACK1 TLN1 TNS2 VCAM1 ZBTB14
Entrez ID		7094	3695
HPRD ID		01726	00948
Ensembl ID		ENSG00000137076	ENSG00000139626
Uniprot IDs		Q9Y490	P26010
PDB IDs		1SYQ 2MWN 4DJ9 6R9T	2BRQ 3V4P 3V4V
Enriched GO Terms of Interacting Partners?
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